ID S7MBZ1_MYOBR Unreviewed; 655 AA.
AC S7MBZ1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 1 {ECO:0000313|EMBL:EPQ01684.1};
GN ORFNames=D623_10009912 {ECO:0000313|EMBL:EPQ01684.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ01684.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
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DR EMBL; KE161092; EPQ01684.1; -; Genomic_DNA.
DR AlphaFoldDB; S7MBZ1; -.
DR eggNOG; KOG3629; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17210; RA_RGL; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR030748; RGL1_RA.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF199; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 119..388
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 535..622
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 417..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 73803 MW; 5B7F3289EAE0ED3A CRC64;
MPRLVLVSRA CFESPQPARC SNSPFLFSSA IASILRAWLD QCGEDFREPP HFPCLQKLLD
YLKRMMPGSD PERRAQNLLE QFHKQEVEAD NGFANTISCR LEEEEEPEAG GSAEFTCFSE
DLVAEQLTYM DAQLFKKVVP HHCLGCIWSQ RDKKENKHLA PTIRATISQF NTLTKCVVST
ILGGKELKTQ QRARIIEKWI NIAHECRILK NFSSLRAIVS ALQSNSIYRL KKTWAAVPKE
RMLMFEELSD IFSDHNNHLT SRELLMKEGT SKFANLDSSV KENQKRTQRR LQLQKDMGLM
QGTVPYLGTF LTDLTMLDTA LQDYIEGGLI NFEKRRREFE VIAQIKLLQS ACNSYCMTPD
QKFIQWFQRQ RLLTEEESYA LSCEVEAAPD ASATSPKPRK SMVKRLSLLF LGSDIITSST
PSKEQPKSTA SGSSGESMDS VSVSSCESNH SEAEEGSITP LDTPDEPQKK LSESSSSCSS
IHSMDTNSSG MSSLINPLSS PPTCNNNPKI HKRSVSVTSI TSTVLPPVYN QQNEDTCIIR
ISVEDNNGNM YKSIMLTSQD KTPAVIQRAM LKHNLDADPA EEYELVQVIS EDKELVIPDS
ANVFYAMNSQ VNFDFILRKK NSTEDPVKLR SRTSLTLPRT AKRGCWSNRH SKITL
//
