ID S7MH69_MYOBR Unreviewed; 2556 AA.
AC S7MH69;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Utrophin {ECO:0000313|EMBL:EPQ03291.1};
GN ORFNames=D623_10035769 {ECO:0000313|EMBL:EPQ03291.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ03291.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|PIRNR:PIRNR002341}.
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DR EMBL; KE161334; EPQ03291.1; -; Genomic_DNA.
DR eggNOG; KOG4286; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd21232; CH_UTRN_rpt1; 1.
DR CDD; cd21234; CH_UTRN_rpt2; 1.
DR CDD; cd00176; SPEC; 7.
DR Gene3D; 1.20.58.60; -; 11.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035436; Dystrophin/utrophin.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF449; -; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00435; Spectrin; 10.
DR PIRSF; PIRSF002341; Dystrophin/utrophin; 4.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 16.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 11.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002341};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR002341};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002341};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR002341};
KW Membrane {ECO:0000256|PIRNR:PIRNR002341};
KW Postsynaptic cell membrane {ECO:0000256|PIRNR:PIRNR002341};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|PIRNR:PIRNR002341}.
FT DOMAIN 31..135
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 150..255
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1437..1458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 449..476
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1140..1229
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1724..1791
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1945..1972
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2150..2177
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1438..1452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2556 AA; 293415 MW; E60E2EE36D591B62 CRC64;
MAKYGEHEAR PDDGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK PPISDMFTDL
KDGRKLLDLL EGLTGASLPK ERGSTRVHAL NNVNRVLQVL HQNNVDLVNI GGTDIVDGNH
KLTLGLLWSI ILHWQVKDVM KDIMSALQQT NSEKILLSWV RQSTRPYSQV NVLNFTTSWT
DGLAFNALLH RHKPDLFSWD RVVKMSPTER LEHAFGQAQT YLGIEKLLDP EDVAVQLPDK
KSIIMYLTSL FEVLPQQVTI DAIREVETLP RKYKRECEEG DMNIQSSVPE EEHGSPRADT
PSTVTEVDMD LDSYQTALED VLTWLLSAED TFQEQDDISE DVEEVKEQFA THEAFMMELT
AHQSSVGSVL QAGNQLITQG TLSDEEEFEI QEQMTLLNAR WEALRVESMD RQSRLHDVLM
ELQKQQLQQL SAWLTLTEER IQKMETCPLD DDLQSLQKLL EDHKSLQNDL EAEQVKVNSL
THMVVIVDEN SGESATAVLE DQLQKLGERW TAVCRWTEER WNRLHEINIL WQELLEEQCL
LKAWLTEKEE ALNKVQTSNF RDQKELSISV RRLAILKEDM EMKRQALDQL SEIGQDVSQL
LDNPKASKKI NSDSEELTQR WDSLVQRLED SSNQVTQAVG KLGMSQIPQK DLLETVHIRE
QVTTKRSKQE LPPPPPPKKR QIPVDMEVKK KFDALSAELL DWILKSKTAI QATEIKEYKK
MQETSEMKKK LKGIEKEQTE RRPRLDELNK TGQILLEQMG KEGLPTEDIK HILEKVLSEW
KTVSQHLEDL ARKIQLQEDT NTYFKQLDEL DKTIKTKEEW LEHAPSSASP QQALRSVKRE
LTSLLGLHPR IETVRASCAA LKSRPSAPDF VQQSFERLLG RYQSVQQDLE DRQQQLENEM
SQPGHAYLET LRTLKDMLND LESKAQTSLD VLNEPAKVEK ALQEKKSQPG HVYLETLRTL
KDMLNDLESK AQTSLDVLNE PAKVEKALQE KKALDEILEN KKPTLFKLAE ETKALEKNVS
PDVGKMYNQE FNDVQGKWNK VKVKVSKDLH LLEEMIPKLR AFEADSKVIE KWMEGAKDFL
MEEQAVQGDA EGLQRQLDQC SAFVNEIDTV ESSLKDMKEV ETHLRSCPVA GIKTWVQTKL
VDYQTQLEKC SREISIHKNR LSERQEKVVN LKKDLSEMQE WMTQAEEEYL ERDFEYKSPE
ELESAVEEMK RAKEDVLQKE VRVKILKDNI KLMAAKVPSG GQELTSELNV VLENYQLLCN
RIRGKCHTLE EVWSCWIELL HYLDLETTWL NTLEERMRST EALPEKADAI NEALESLESV
LRHPADNRTQ IRELGQTLID GGILDDIISE KLEAFNSRYE ELSHLAESKQ ISLEKQLHVL
RETDHMLQVL QESLRELDKQ LTTYLTDRVD ALQVPQEAQK MQAEISAHEL TLEELRRNAR
SQPPTSPEGR TARGGSQMDV LQRKLREVST KFQLFQKPAN FEQRMLDCKR VLDGVKAELH
VLDVKDVDPD VIQTHLDKCM KLYKTLSEVK LEVETVIKTG RHIVQKQQTD NPKGLDEQLT
SLKVLYNDLG AQVTEGKQDL ERASQLARKM KKEAASLSEW LSVTETELVQ KSNSEGLLGD
LDTEISWAKN ILKDLEKRKA DLNTITESSA ALQNLVEGSE PVLEERLCVL NAGWSRVRTW
TEDWCNTLMS HQNQLEIFDG NVAHISTWLY QAEALLDEIE KKPASKQEEI VKRLLSELDD
ARLQVEDVRD QAVVLMNARG GSCRELVEPK LAELNRNFEK VSQHIESANL LIGQEPLSYQ
SLATTEALEA DVPFSDLEKL ESDIEYMLKV VEKPLESSNE DEKMDEERAQ IEEVLQRGEQ
MLHQPMEDNK KEKIRLQLLL LHTRYNKTKA IPIQQRRTSQ LASGIKSSLL PPDYLVEINK
VLLSMDDAEL SLNTPELSTA VYEDFSFQED ALKNIKDQLD KLGEQIAVIH EEQPDVILEA
SVPEVIQIRD TLTQLDAKWD RINRMYNDRK GYFDRTMEEW RQFHCDLNDL TQWTTEAEEL
LADTLAPDGG LDLEKARVHQ QELEEGISSH QPSFAALNRT GDGIVQRLSP TDGSFLKDKL
AGLNQRWGAI IAEVKDRRPR LKGESKQVME YRKRLDEIIC WLTKAENAVQ KRSTTELEEN
RKELTDLNQE MDVQAEKLKW LNRTELEMLS DKSLSLHERE KISESLRTVN STWNKVCRDV
PSALKECVPE PCSVSQSRTA AHPGALKVVL VSSASEPSAQ SPRTSEISLP ADLDKTITEL
ADWLVLIDQM LKSNIVTVGD VEEINKTVSR MKITKADLEQ RHPQLDYVFT LAQNLKNKAS
SLDVRTAITE KLEKVRNQWD STQHGVELRQ QQLEDMVIDS LQWDDHREET EELMRKYEAR
LYILQQARRD PLIKQISDNQ ILLQELGPGD GIVMAFDNIL QKLLGKYGSD DTRNVKETTE
YLKASWINLK QSIADRQNAL EAELRAVQAS RKDLENFLKW LQEAETTVNV LADASQRENA
LQDTVLAKEL TQQMQASAQK NVTSACLPLR FITIQK
//
