ID S7MKT3_MYOBR Unreviewed; 1141 AA.
AC S7MKT3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Fibrinogen alpha chain {ECO:0000256|ARBA:ARBA00017850};
GN ORFNames=D623_10031307 {ECO:0000313|EMBL:EPQ04120.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ04120.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-
CC identical chains (alpha, beta and gamma). The 2 heterotrimers are in
CC head to head conformation with the N-termini in a small central domain.
CC {ECO:0000256|ARBA:ARBA00025974}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; KE161484; EPQ04120.1; -; Genomic_DNA.
DR AlphaFoldDB; S7MKT3; -.
DR eggNOG; KOG2579; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005577; C:fibrinogen complex; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0030168; P:platelet activation; IEA:InterPro.
DR GO; GO:0051258; P:protein polymerization; IEA:InterPro.
DR CDD; cd00087; FReD; 2.
DR Gene3D; 1.20.5.50; -; 2.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 2.
DR Gene3D; 4.10.530.10; Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2; 2.
DR InterPro; IPR037579; Fibrinogen.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR012290; Fibrinogen_a/b/g_coil_dom.
DR InterPro; IPR021996; Fibrinogen_aC.
DR InterPro; IPR020837; Fibrinogen_CS.
DR NCBIfam; NF040941; GGGWT_bact; 2.
DR PANTHER; PTHR47221; FIBRINOGEN ALPHA CHAIN; 1.
DR PANTHER; PTHR47221:SF3; FIBRINOGEN ALPHA CHAIN; 1.
DR Pfam; PF08702; Fib_alpha; 2.
DR Pfam; PF12160; Fibrinogen_aC; 1.
DR Pfam; PF00147; Fibrinogen_C; 2.
DR SMART; SM00186; FBG; 2.
DR SMART; SM01212; Fib_alpha; 2.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 2.
DR SUPFAM; SSF58010; Fibrinogen coiled-coil and central regions; 2.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 2.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 2.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1141
FT /note="Fibrinogen alpha chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004554314"
FT DOMAIN 170..416
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT DOMAIN 898..1139
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 681..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 59..89
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 546..587
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 885..904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 128142 MW; AB4F713A0456924D CRC64;
MHWSLHPRSL ILYFYTLLFL SSTCLAFVPP TDNCCISDKR FGRYCPTTCG IADFLLNYQT
EVDQDLQSVE ETLRKIKNNT SEAKELIKQI QSVDNPDGLP KSDKIEAAVK ESQKMMEDII
KFEALIISHE SSIRFLKDIY NSNNQKIATL KQKVVQLEAK CQEPCKDTVK IHDITGRDCQ
DIANKGGKES GLYFIKPLTT QQQFLVYCEM EKNGNGWTVL QKRLDGSEDF KKNWIQYKEG
FGHLSPTGTT EFWLGNEKMH LITTQSAIPY VLRVELEDWT GRIATADYAM FSVGNEADKY
RLKYAYFMSG DAGDAFDGFD FGDDPSDKFF TSHNGMQFST WDNDNDKFDG NCAEQDGSGW
WMNKCHAGHL NGVYYQGGTY SKTSTPNGYD NGIIWATWKS RWYSMKKTTM KIIPFNRVNI
GEGQQHHLGG SKQTTETDKG EFILEGGGVR GPRPDPRPAS SCREKEWPFC ADEDWNQKCP
SGCRVQGLIN EVNQDFTNRI NKLTNELFDY QKNNKDSSSL IRNIIEQYRR HFADSHHNDN
AYHRVSEDLR SRLETLNRKV TEQVQQIQLL QKNVKAQLVD MKRLEVDIDI KIRSCQGSCS
RAVARTIDLQ DYEGQQKQVE DLIAKDLLPP KYTQHLPLLK MRPSLDFVPR VDKDKLQATF
PELKPMLEMQ QMAMVIERSG TAGTHRGDSA VRGAGSAPET PRKPGPGSSG NPKPGSSGPG
GAGTRNHERP DSTGHGSVRF DSPDWGTFSE SSESLSPGTK KEYHHTGKLV TSEGGKELLI
GKEKVISGGL TSSRSSCSKT ITKIVIGAGG RKQVTKEEVT SEDGSNCGDA TDLDSFHTSS
RGSLDEFRHR FPEEAAFLDL SPGLKEFHSM GSTSAPFGNL EETSSHHVSE THTTKKGRAR
ARTTRDCDDV LQTHPSGAQS GLFNIKLPGS SKIFSVYCDQ ETNLGGWLLI QQRMDGSLNF
NRTWQDYKRG FGSVNDKGEG EFWLGNEYLH SLTLRGSVLR VELEDWAGNL AYAEYHLRVG
SEAEGYALQV SSYKGTAGNA LIEGSVEEGT EYTSHNGMQF STFDRDADQW EENCAEVYGG
GWWYNNCQAA NLNGIYYPGG FYDPRNNSPY EIENGVVWVP FRGADYSLRA VRMKIRPLVT
Q
//
