ID S7MSZ3_MYOBR Unreviewed; 1936 AA.
AC S7MSZ3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Rho GTPase-activating protein 21 {ECO:0000313|EMBL:EPQ07534.1};
DE Flags: Fragment;
GN ORFNames=D623_10029508 {ECO:0000313|EMBL:EPQ07534.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ07534.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
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DR EMBL; KE162237; EPQ07534.1; -; Genomic_DNA.
DR eggNOG; KOG4407; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 1.20.5.220; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 29..138
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 909..1018
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1126..1318
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1334..1380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1397..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1575..1620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1638..1667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1686..1716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1751..1782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1838..1936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..905
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1099
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1355..1379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1516..1548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1592..1615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1647..1667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1686..1711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1870..1919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EPQ07534.1"
SQ SEQUENCE 1936 AA; 214273 MW; B6AC19973FEC2C37 CRC64;
VSKNKDGKEQ SETVSPSEDE AFSWPGPKTV MLKRTSQGFG FTLRHFIVYP PESAIQFSYK
DEENGNRGGK QRNRLEPMDT IFVKQVKEGG PAFEAGLCTG DRIIKVNGES VIGKTYSQVI
ALIQNSDTTL ELSVMPKDED ILQVLQFTKD VTALAYSQDA YLKGNEAYSG NARNIPEPPP
VCYPWLPSAP SDMAAPAEVS PPDSSSSKQQ TSTPVLTQPG RAYRMEIQVP PSPTDVAKSN
TAVCVCNESV RTVIVPSEKV VDLLPNRNNH TVPSHRTEEV RYGISEQPSL KTVSRTTSPS
SSIPTAHLIH QAPGSRSLEP SGILLKSGNY SGHSEGISSK RSQALDSPSV SVNHYSPNSH
QHIDWKNYKT YKEYIDNRRL HMGCRTIQER LDSLRAASQS TTDYNQVVPN RTTLQVRRRS
ASHDRVPQSV QIRQRSVSQE RLEDSVLMKY CPRSASQGAL TAPPVSFSNH RTRSWDYIEG
QGETLENVTS ESQMPDSNGE RKQTYKWSGF TEQDDRRGIY ERPRQQEIHK SFRGSNFTVA
PSVVNSDIRR TSGRGVGSVS QFIKIPPDLK TVQSNRSFQT TCGMSLPQGI SQNRSPLVKV
RSNSLKAPSV QVTKPSFNQN SFVSIKDQRP VNHLHQNSLL NPQTRLRSES VPGQQVEPGK
APCLSGASKS APQVNENSGT SEGELPVTQR SQDVHLQAAE IQQSDTLDNK ETVILREKPP
SGRQTPQPLR HQSYILAVND HETASDTTCW LPNDARREVH IKRIEERKAS STSPPADSLA
SIPFIDEPTS PSIDHDIAHI PASAVISAST SQAPSLATVP PSLTTSAPLI RRQLSHDQES
VGPSSLDGQP NSKTERSKSY DEGLDDYRED AKLSFKHIST LKGNKMTDSQ KSSEDSGSRK
DSSSEVFSDA AKEGWLHYRP LVTDKGKRVG GSIRPWKQMY VVLRGHSLYL YKDKREQMIP
SEEEQPISVN ACLIDISYSE TKRKNVFRLT TSDCECLFQA EDRDDMLAWI KTIQESSNLN
EEDTGVTNRD LISRRIKEYN SLMSSKAEQL PKTPRQSLSI RQTLLGAKAE PKTQSPHSPK
EESERRLLSK DETSPPKDKG TWRKGIPSIM RKTFEKKPTA TGTFGVRLDD CPPAHTNRYI
PLIVDICCKL VEERGLEYTG IYRVPGNNAA ISSMQEELNK GMADIDIQDD KWRDLNVISS
LLKSFFRKLP EPLFTNDKYA DFIEANRKED PLDRLKTLKR LIHDLPEHHY ETLKFLSAHL
KTVAENSEKN KMEPRNLAIV FGPTLVRTSE DNMTHMVTHM PDQYKIVETL IQHHDWFFTE
EGAEEPLTTV QEENTVDSQP VPNIDHLLTN IGRTGVSPGD VSDSATSDST KSKGSWGSGK
DQYSRELLVS SIFAAASRKR KKPKEKAQPS SSEDELDNVF FKKENAEQCQ NDTKAESKKE
SEASGRKQRI AMSKENNAKK DSSATKDDKT SLQKESVPSE EPSPPHTAKR SKSPSLSCRL
AVLKEGARPP GAQKPSQCEE TGSDSGTLLS TSSQASLARF STKKSTSPEA KYGEFLANVS
TITSDYSTTS SATYLTSLDS SRLSPEVQSV AESKGDEADD ERSELISEGR PVETDSENDF
PVFPAAWASE RLFRGKLQEA PRASRRNSEG SEASCTEGSL TPSLDSRRQL FSSHKLIECD
TLSRKKSARF KSDSGSLGDA RNEKEPPSIT KVFDVMKKGK STGSLLAPAR SESEKQEPTW
KTKIADRLKL RPRAPADDMF GVGSQKLNAE TAKRKNIRRR HTLGGHRDVS EISILNFWKV
PEQSGGESEL SAVTRLKPKC SAQDLSISDW LARERLRTSA SDLSRGEVGD PQPERSGALE
IPTVDTPVSF QADAGGSPST LASTPRPLLS IPPQSPDQIN GGSFQNMSQN ASSAANAPPH
KLSESPGNKA QLHPCL
//
