ID   S7MV21_MYOBR            Unreviewed;       721 AA.
AC   S7MV21;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Glycerophosphodiester phosphodiesterase domain-containing protein 4 {ECO:0000313|EMBL:EPQ08294.1};
GN   ORFNames=D623_10028559 {ECO:0000313|EMBL:EPQ08294.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ08294.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC       family. {ECO:0000256|ARBA:ARBA00007277}.
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DR   EMBL; KE162454; EPQ08294.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7MV21; -.
DR   eggNOG; KOG2258; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR   InterPro; IPR030395; GP_PDE_dom.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   PANTHER; PTHR23344:SF13; GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR23344; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR   Pfam; PF03009; GDPD; 1.
DR   SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR   PROSITE; PS51704; GP_PDE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        240..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        323..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        348..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        656..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          385..644
FT                   /note="GP-PDE"
FT                   /evidence="ECO:0000259|PROSITE:PS51704"
SQ   SEQUENCE   721 AA;  82610 MW;  81666B474E15D717 CRC64;
     MVGVGCSRMV EQVSGDARPR QGAGRCHWGK PPGVTENSLL PCAAIPPGAR ICCWRQPCLH
     LLPAPITQRH QRVQVAAAGP DCPSGLLHLP LLLRGNWGSS HCSHPLTALA PIALHCEGCE
     QGWRCERMGV ATAGVGTGAM TGGAGQGDYK AAKFTINLYV VNEPWVFSLT WCSRINLVTT
     DNIQLPRQIN YPDYSMVEQL FYPFLVIAFC VSLVLLFVWI ETSNEYHGFD WVVYLLTGYW
     YFWSILLLSL FGILVVYTSL LLILGFLLIR EGYELYLYWC HKILVMLVIL ICAFFLSILC
     IYWKDRWLTF GLSLKVFAPH VHLTMITLMV LLSWPVAYYL VHLEQEAAQV AIGLPFFLIL
     LFLFVVPWGF YSPCVENKNK LGPKPALFGH RGAPMLAPEN TMMSFEKAVE NDAFGLETDV
     FLSIDEVPFL MHDHNLRRTT NIREVKPNES YTATSFFYWK FLSTLNAGEW FVDPWKKPFY
     NMKPLSEADE EKAGSQKIPK LSDYLDIARK TNKYVIFDLN GPPPKHPLRS TYVRRVVDVI
     LKSKIEQHLV YWLPGFDRDY VRWRAPNFQH VGRLDPVAEL KKENISIINV DYKRLFHNGL
     SDYKAANFII NLYIVNEPWV FSLAWCSKIN SVTTDNIVLL RQINYPYYAM TPKSYVFLWV
     LLDCISAVFI FTVFYFHWWR ENLREQVFER TSSYTGKVGG LPHCYPLPQG MGSAFHVTDK
     C
//