ID   S7MZE2_MYOBR            Unreviewed;       417 AA.
AC   S7MZE2;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Complement component C8 beta chain {ECO:0000313|EMBL:EPQ09964.1};
GN   ORFNames=D623_10020952 {ECO:0000313|EMBL:EPQ09964.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ09964.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC       {ECO:0000256|ARBA:ARBA00009214}.
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DR   EMBL; KE162868; EPQ09964.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7MZE2; -.
DR   eggNOG; KOG3535; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005579; C:membrane attack complex; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR048831; C8A_B_C6_EGF-like.
DR   InterPro; IPR001862; MAC_perforin.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR020863; MACPF_CS.
DR   PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR   PANTHER; PTHR45742:SF5; COMPLEMENT COMPONENT C8 BETA CHAIN; 1.
DR   Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   PRINTS; PR00764; COMPLEMENTC9.
DR   SMART; SM00457; MACPF; 1.
DR   PROSITE; PS00279; MACPF_1; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
PE   3: Inferred from homology;
KW   Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          25..368
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
SQ   SEQUENCE   417 AA;  47241 MW;  9B3E168D53245612 CRC64;
     MLQLPAAVPL SPHTDSHLPR LHNPLWTADE SNARAERPPY LESNAVNGSL AKSRQTRSVD
     VTLRPIDCEL SSWSSWTRCD PCQKKRTQGK YEFALTEYES YSDFERNVTK AERSQSSFSI
     GFTIPGIFEL GMNMANDNGQ RFVSRTKRFS HTRSRFLHAR SDLEVARYKL KSRSLMLHYE
     FLQRVRQLPL EYAYGEYRDL FRDFGTHYIT EAVLGGIYEY TLVMNQEAME KADYSLKDIH
     ACAQAGFRIG AAFEAVYLKL GVSMALCMGV LKEIKDRNNR KSMVEDLVVR VRGGASEYVT
     ALAYKDLPTA DLMQEWGDAV QYNPDIIKIK ASPLYELVTS TDFAYSSTVK QNMKQALEEF
     QKEVSSCLCA PCKGNGVPVL KESHCDCICP SGFEGQGCEI TSRKSKEPLR VGGEREH
//