ID   S7P8Y0_MYOBR            Unreviewed;       715 AA.
AC   S7P8Y0;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Epididymis-specific alpha-mannosidase {ECO:0000313|EMBL:EPQ06698.1};
GN   ORFNames=D623_10005515 {ECO:0000313|EMBL:EPQ06698.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ06698.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KE162038; EPQ06698.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7P8Y0; -.
DR   eggNOG; KOG1959; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 2.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF28; EPIDIDYMIS-SPECIFIC ALPHA-MANNOSIDASE; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 2.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..715
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004543862"
FT   DOMAIN          29..100
FT                   /note="Glycoside hydrolase family 38 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01074"
FT   DOMAIN          150..398
FT                   /note="Glycoside hydrolase family 38 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01074"
FT   DOMAIN          516..674
FT                   /note="Glycosyl hydrolase family 38 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07748"
SQ   SEQUENCE   715 AA;  81273 MW;  53C6AFA5D1EDC5FB CRC64;
     MGLPRWLPLF AQLVVLQLPG TWAEDTIRVF VVPHSHMDVG WLYTVQENMQ IYAASVYTSV
     VRELTLKEHR RFIAVEQEYF RLWWDQFASR TQKLQVRELL AHVPAEPPRS GVDLAFPLCL
     PHQVRELLAH VPAEPPRSGV DLALSSGLPH QVRELLAHGR LEFVSGGQVM HDEAVTHFDD
     QILQLTEGHG FLYETFGIRP QFSWQVDSFG ASATTPTLFA LAGFNAHVIS RIDYEIKEAL
     MHAQEMQFVW RGSQSLAEQQ EIFTHVLDFY GYCSVGYSWE GEALLLTQFQ NEEHNNLNDP
     VTVSNIGMYV ERFVLDVKSR ASLYRTPHIL WPWGCDRTFF NAGVQFANMD LLLHFLNTQA
     SQLGITVEYA TLGAYFRAVH AHNATWRTHG HQDFLPYSSG SEPKGHSAAV YNPLAWTVTT
     LINLTVSFPS VTVTDESGHP VKAQVQSSKE IPHKYDLYVL TTIPGLSYRY YSIRPTEQAP
     EGKQATTATM AFTSKLDRKP RKPSTRPWGK KLVSVKNDCY TVFLDPDTNL MHSIWERQSN
     RTVSVTQEFL EYTVSGDKND APVSDNYVFL PKGPADPAWE AVRVEMVRGR LLTEIRQYFY
     RTLEAKEHTY AIYSRLAHVP LGFDRELLCH HLEQELRVGP LQVNREAVLR TSTDLQSLRV
     LHSDSNAFQM QRRLHRDYPA HTISRVRWRG LGAGASTGAP LLPVGVEPRL GQPGV
//