ID S7PL10_MYOBR Unreviewed; 1046 AA.
AC S7PL10;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 2 {ECO:0000313|EMBL:EPQ08802.1};
GN ORFNames=D623_10004255 {ECO:0000313|EMBL:EPQ08802.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ08802.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
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DR EMBL; KE162539; EPQ08802.1; -; Genomic_DNA.
DR AlphaFoldDB; S7PL10; -.
DR eggNOG; KOG3629; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0019885; P:antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17211; RA_RGL2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR008056; Tapasin.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF363; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR01669; TAPASIN.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 168..274
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 357..481
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 512..782
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 917..1004
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 111961 MW; 878B3D8CB470E809 CRC64;
MVSVSSPVVS LSSLLRPQSE SQPEPAVITM ATAVLTVVTH TPTTRVRLGQ DALLDLSFAY
MPPTPEATAS LAPGPPPFGL EWRHQHQGKG HLLLAATPGL DGQTPAARDG AVAFAAWDDN
EPWGPWTGNG TLRLPAVQPR QEGAYMATVH LSYLQGQVTL ELAVQKPPKV SLTPAPLVWA
APGEAPPELL CLVSHFYPAA GLEVEWELRG PNGSIQEAKG HQWLSALHHH SDGSVSLSGL
LQPAPVTSAQ HGARYACRVH HPSLPPLGRS AEVTLEVAGR SGPSLEDGIG LFLSAFLLLG
LLKVLCWAAV YLSTSKKSKE KAPVSVRDEE EDGATFTVTS RQYRSLDPLA PTPPPRSSRR
LRAGTLEALV RHLLDVRTSG ADVTFTATLL ATHRAFTSTP ALLGLMADRL EALESHPADE
LERTKGVAIS VLSTWLASHP EDFGSEVKGQ LDRLESFLLR TGYAAGEGVG GGSADLIRNL
RSRVDPQAPD LPKPLALPGD PPADPTDVLV FLADHLAEQL TLLDAELFLN LVPSQCLGGL
WGHRDRPGHS HLCPSVRATV TQFNKVAGAV VSSVLGAIST GEDPGEVTIR PLRPPQRARL
LEKWIRVAEE CRLLRNFSSV YAVVSALQSS PIHRLRAAWG EAARDSLRVF SSLCQIFSEE
DNYSQSRELL LREVKGQPSL EPNSRKALKS GSRGGGVVPY LGTFLKDLVM LDAASKDELE
NGYINFDKRR KEFAVLSELR RLQNECRGYD LRPDPDIQQW LQGLRPLTEA QSHRVSCEVE
PPGTGDPPAP RVLRPTLVIS QWTEVLGSVG GPTPLVSWDR PNVGGDEVPG NPAPLLTRLA
QHMKWPSVSS LDSALESTPS LQSPAGPSHL SPPASSPRPS RGHRRSASCG TPLSGGAEGA
SRGPASGGGG SGPGASDCRI IRVQMELGED GSVYKSILVT SQDKAPSIIS RVLKKNNRDF
AVASEYELVQ LLPGERELTI PPSANVFYAM DRASHDFLLR QRRRSSTATP GLASGPSASG
TPPSEGGGGS FPRIKATGRK IARALF
//
