ID S7PYA3_MYOBR Unreviewed; 144 AA.
AC S7PYA3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Sperm surface protein Sp17 {ECO:0000256|ARBA:ARBA00014863};
DE AltName: Full=Sperm autoantigenic protein 17 {ECO:0000256|ARBA:ARBA00031837};
GN ORFNames=D623_10021877 {ECO:0000313|EMBL:EPQ13542.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ13542.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- FUNCTION: Sperm surface zona pellucida binding protein. Helps to bind
CC spermatozoa to the zona pellucida with high affinity. Might function in
CC binding zona pellucida and carbohydrates.
CC {ECO:0000256|ARBA:ARBA00025518}.
CC -!- SUBUNIT: Homodimer. May interact with ROPN1.
CC {ECO:0000256|ARBA:ARBA00044028}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; KE163720; EPQ13542.1; -; Genomic_DNA.
DR RefSeq; XP_005875618.1; XM_005875556.2.
DR AlphaFoldDB; S7PYA3; -.
DR GeneID; 102262414; -.
DR KEGG; myb:102262414; -.
DR CTD; 53340; -.
DR eggNOG; ENOG502S4R6; Eukaryota.
DR OrthoDB; 5472182at2759; -.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:InterPro.
DR CDD; cd12100; DD_CABYR_SP17; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.890.10; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; 1.
DR InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR InterPro; IPR047579; DD_CABYR_SP17.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR012105; Sp17.
DR PANTHER; PTHR10699; NEUROMODULIN; 1.
DR PANTHER; PTHR10699:SF11; ZGC:153721; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF02197; RIIa; 1.
DR PIRSF; PIRSF016533; Sp17; 1.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00394; RIIa; 1.
DR SUPFAM; SSF47391; Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 14..51
FT /note="RIIa"
FT /evidence="ECO:0000259|SMART:SM00394"
FT REGION 71..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 144 AA; 16688 MW; 051AC3D8F718EC3C CRC64;
MSIPFSNTHY RIPQGFGNLL EGLTREILRQ QPENIPSFAA AYFEDLLEKR EKTNFDPAEW
GSKVDDRFYN NHAFKEQEPA EKENSQASEK VETPVTALDS SDENKEKEEL AAVKIQALFR
GHLAREEVKK MKQEELEEKT QEDN
//
