ID S7Q4L7_MYOBR Unreviewed; 3082 AA.
AC S7Q4L7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Transformation/transcription domain-associated protein {ECO:0000313|EMBL:EPQ15807.1};
GN ORFNames=D623_10032126 {ECO:0000313|EMBL:EPQ15807.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ15807.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR EMBL; KE164183; EPQ15807.1; -; Genomic_DNA.
DR eggNOG; KOG0889; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 1926..2498
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2723..3046
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3050..3082
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1263..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1775..1796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3082 AA; 348470 MW; BDBE35E50AE6F05D CRC64;
MMQLLSVSRS YLGKHPGLGK CSAKPAWINT IYQASIFEVE LQRYGFSFWV MLTHNFHLHS
NAPSVELHHL CSVKHGEKDK EDKQTFQVTD CRRLVKTLVC GVKTITWGIT SCKAPGEAQF
IPNKQLQPKE TQIYIKLVKY AMQALDIYQV QIAGNGQTYI RVANCRTVRM REEKEVLEHF
AGVFTMLNPF TFKEIFQTTV PYMVERISKN YALEIVASSF LANPTTSALF ATILVEYLLD
RLPEMGSNVE LSNLYLRLFK LVFGSVSLFA AGNEQMLKPH LHKIVNSSME LAQAAEEPYN
YFLLLRALFR SIGGGSHDLL YQEFLPLLPN LLQGLNTLQS GLHKQHMKDL FVELCLTVPV
RLSSLLPYLP MLMDPLVSAL NGSQTLVSQG LRTLELCVDN LQPDFLYDHI QPVRAELMQA
LWHTLLNPAD SISHVAYRVL GKFGGSNRKM LKESQKLHYV LTEVQGPSVT VEFSDCKASL
QLPMGKAIET ALDCLKSANT EPYYRRQAWE VIKCFLVAMM RLEDNKHALY QLLAHPNFTE
KTIPNVIISH RYKAQDTPAR KTFEQALTGA FMSAVIKDLQ PSALPFVASL VRHYTMVAVA
QQCGPFLLPC YRVGSQPSPA MFHSDENGSK GMDPLVLIDA IAICMAYEEK ELCKIGEVAL
AVIFDVASII LGSKERACQL PLFSYIVERL CACCYEQAWY AKLGGVVSIK FLMERLPLTW
VLQNQQTFLK ALLFVMMDST GEVSNGAVAM AKTTLEQLLM RCATPLKDEE RAEEIVAAQE
KSFHHVTRDL VREVISPNST VRKQAMHSLQ VLAQVTGKSV TVIMEPHKEV LQDMVPPKKH
LLRHQPANAQ IGLMEGSTFC TTVQPRLFTM DLNVVEHKVF YTELLNLCEA EDSALTKLPC
YKSVPSLVPL RIAALNALAA CNYLPQSREK IIAALFKTLN STNSELQEAG EACMRKFSEG
ATIGVDQIHT HMRPLLMMLG DHRSLTLNVV NRLTSVTRLF PNSFNDKFCD QMMHILNPAF
LYSFEKGEGE QLLGPPNLEG DNPESITSVF ITKVLDPEKQ EDMLDSLRIY LLQYATLLVE
HAPHHIHDNN KNRNSKLRRL MTFAWPCLLS KACVDPACKY SGHLLLAHII AKFAIHKKIV
LQVFHSLLKA HAMEAQTIVR RAMAILTPAV PARIKDEHQM LTHWTRKIIV EEGHTVPQLV
HSMHLIVQHF KVYYPVRHHL VQHMVSAMQR LGFTPSVTIE QRRLVVDLAE VVIKWELQRI
KDQQPDSDMD PNSSGEGVNS VSSSIKRGLS VDSAQEVKRF RTATGATSAV FGRSQSLPGA
DSLLAKPIDK QHTDTVVNFL IRVACQVNDN TNTAGSPGEV LSRWCVALLK TALRPDMWSK
SELELQWLDK LLLSVEQPNQ VNYGNICTGL EVLSSLLTVL QSPAILSSFK PLQRGIAACM
TCGNTKVLRA VHSLLSRLMS IFPTEPSTSS VASKYEELEC LYAAVGKVIY EGLTNYEKAT
NANPSQLFGT QSACNNPSYI DRLISVFMRT LQKMVREHLN PQAASGTTEA TSGTSELVIL
SLELVKTRLA VMSLEMRKNF IQAILTSLIE KSLDAKILRA VVKIVEEWVK NNSPMAANQT
PTLREKSILL VKMMTYIEHR FPEDLELNAQ FLDLVNYVYR DEALSGSELT AKLEPAFLSG
LRCAQPLIRA KFFEVFDNSM KRRVYERLLY VTCSQNWEAM GNHFWIKQCI ELLLAVCEKS
TPIGTSCPGA MLPSITNVIN LADSHDRAAF AMVTPVKQEP QERENSESKE EDVEMDIELA
PGDQTSTPKT KELSEKDIGT QLHMLTNRHD KFLDTLREVK TGALLGAFVQ LCHISTTLAE
RTWGQLFPRV WEILSDRQQH ALAGEISPFL CSGSHQVQRD CQPSALNCFV EAMSQCVPPI
PIRPCVLKYL GKTHNLWFRS TLMLEHQAFE KGLSLQVKPR QTTEFYEQES ITPPQQEILD
SLAELYSLLQ EEDMWAGLWQ KRCKYSETAT AIAYEQHGFF EQAQESYEKA MDKAKKEHER
SNASPALFPE YQLWEDHWIR CAKELNQWEA LTEYGQSKGH INPYLIMECA WRVSNWTAMK
EALVQVEVSC PKEMAWKVNM YRGYLAICHP EEQQLSFIER LVEMASSLAI REWRRLPHVV
SHVHTPLLQA AQQIIELQEA AQINAGLQPT NLGRNNSLHD LKTVVKTWRN RLPIVSDDLS
HWSSVFMWRQ HHYQAIVTAY ENSSQYDPSS NNAMLGVHAS ASAIIQYGKI ARKQGLVNVA
LDILSRIHTI PTVPIVDRFQ KIRQQVKCYL PLAGVVGKNE CMQGLEVIES TNLKYFTKEM
TAEFYALKGM FLAQINKSEE ANKAFSAAVQ MHDVLVKAWA MWGDYLENIF VKERQLHLGV
SAIICYLQAC KHQNESKSRK YLAKVLWLLS FDDDKNTLAD AVDKYCIGVP PIQWLAWIPQ
LLTCLVGSEG KLLLNLISQV GRVYPQAVYF PIRTLYLTLK IEQRERYKSD PGPIRATAPM
WRCSRIIHMQ RELHPTLLSS LEGIVDQMAW FRENWHEEVL RQLQRGLAKC YSVAFEKSGA
VYDAKITPHT LNFVKKLVST FGVGPENISN VSTMFSSADS ESLTRRVQAT VQDPVFQKLK
GQFTTDFDFS VPGSMKLHNL ISKLKKWIKV LEAKTKQLPK FFLLEEKCRF LSNFSAQTAE
VGIPGEFLVP KPTHYYIKIA RFLPRVEMVQ KHNTTARRLS ILGHNGKIYP YLVMNDACPT
ESRREERVLQ LLCLLNPCLE KRKETAKRHL FFTVPRVVAV SPQMRLVGDN PSSLSLVEIY
KRRCAKKGME HDNPISRYYG RLATVQARGT QASHQVLRDI LKEVQSDMVP RGLLKEWALH
TFPDATDYWA FRKTLTIQLA PIGFAEFVLH LDRLNPEMLQ IAQDTGNLNI AYFRFDINDA
TGDLDANRPV PFRLTPNISE FLTTIGVSGP FTASMIAVAR CFAQPDFKVD GILKTVLRDE
IIAWHKKTQE DTSSPLSAAG QPENMDRQQL VSLVQKAATA IVTRLHSLAQ FEGGESKVNT
LVAAANSLDN LCRMDPAWHP WL
//
