ID   S7Q8P5_MYOBR            Unreviewed;       845 AA.
AC   S7Q8P5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Calcium-activated chloride channel regulator 1 {ECO:0000256|ARBA:ARBA00041120};
GN   ORFNames=D623_10003849 {ECO:0000313|EMBL:EPQ19758.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ19758.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}.
CC   -!- SIMILARITY: Belongs to the CLCR family.
CC       {ECO:0000256|ARBA:ARBA00006398}.
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DR   EMBL; KE164728; EPQ19758.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7Q8P5; -.
DR   MEROPS; M87.001; -.
DR   eggNOG; ENOG502QRRD; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR004727; CLCA_chordata.
DR   InterPro; IPR013642; CLCA_N.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   NCBIfam; NF041940; choice_anch_X; 1.
DR   NCBIfam; TIGR00868; hCaCC; 1.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF52; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 1; 1.
DR   Pfam; PF08434; CLCA; 2.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00023049};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          238..407
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   845 AA;  92200 MW;  5EA080A23C35C0B0 CRC64;
     MSGCKQGLPI PLRLTPALFC VRPLVDMVTQ ASPYLFEATG KRFYFKNVAI LIPEKWKTKP
     EYMRPKLETY KNADVLVAEP NPPGNDDPYT EQMGNCGEKG ERIHFTPDFI TGKKLPQYGP
     QDITGKNVIK KCQGGSCVTK SCKVDRVTGL FEKGCEFLPD REQTEKASIM FSPSVNSVVE
     FCTEKNHNKE APNLQNQRCN LRSTWEVISG SEDFKKTTPM TTPPPKPTFS LLQIGQRIVC
     LVLDKSGSMK SGDRLKRMNQ AGKLFLLQTV EQGSWVGMVM FDSAAQVQSE LVQINGGAKR
     DALIRKLPTA ASGGTSICSG LRSAFTVIRK KYPTDGAEIV LLTDGEDTSI STCFTEVKQS
     RAIIHTVALG PDAAKELEEL SKMTGGLQTY ASDQAQNNGL IDAFGALSSG NGAVSQRSIQ
     LESTGVTLQA SQWMNGTVIV DSTVGNDTLF LITWTIQPPQ ILLWDPSGKK QGGFVVDTDT
     KMAYLPIPGT AKVGIWNYSL QASSQTLTLT VTTRASSATL PPVTVTSKMN KDKGKFPSPM
     VVYAKVHQGA LPILGASVTA LIESAKGKTV TLELLDNGAG ADATKDDGIY SRYFTAYDTN
     GRYSVKVRAL GGVNAARRRV MPQQNGAMYI PGWIENGEVK WNPPRPEMNK NDLQGKQVCF
     SRTSSGGSFV ASNVPKAPIP DLFPPCQITD LKAKLQGDNR INLTWTAPGD DYDYGRAYKY
     IIGISTSILD LRDKFNESVQ VNTTNLIPKE ANSEEVFVFK PESIPFENGT DLFIAVQAVD
     KVNLMSEISN IARVSLFIPP QTPPETPSPS LPCPEINVNS TIPGIHILKI MWKWLGELQL
     SVALG
//