ID S7ZCG1_PENO1 Unreviewed; 1062 AA.
AC S7ZCG1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PDE_02893 {ECO:0000313|EMBL:EPS27949.1};
OS Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=933388 {ECO:0000313|EMBL:EPS27949.1, ECO:0000313|Proteomes:UP000019376};
RN [1] {ECO:0000313|EMBL:EPS27949.1, ECO:0000313|Proteomes:UP000019376}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=114-2 / CGMCC 5302 {ECO:0000313|Proteomes:UP000019376};
RX PubMed=23383313; DOI=10.1371/journal.pone.0055185;
RA Liu G., Zhang L., Wei X., Zou G., Qin Y., Ma L., Li J., Zheng H., Wang S.,
RA Wang C., Xun L., Zhao G.-P., Zhou Z., Qu Y.;
RT "Genomic and secretomic analyses reveal unique features of the
RT lignocellulolytic enzyme system of Penicillium decumbens.";
RL PLoS ONE 8:E55185-E55185(2013).
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DR EMBL; KB644410; EPS27949.1; -; Genomic_DNA.
DR AlphaFoldDB; S7ZCG1; -.
DR STRING; 933388.S7ZCG1; -.
DR eggNOG; KOG2378; Eukaryota.
DR HOGENOM; CLU_005431_1_0_1; -.
DR OrthoDB; 4819765at2759; -.
DR PhylomeDB; S7ZCG1; -.
DR Proteomes; UP000019376; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF13233; Complex1_LYR_2; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000019376}.
FT DOMAIN 422..547
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 676..914
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..265
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1062 AA; 118125 MW; 7A2ED34AD78298F4 CRC64;
MPAGMFQRPG MGSRTSSAPE GELHRLEAGR RPKSATKIGH ALLEEDEGCS RAGQDTPNTV
PSLDRNEEEP SKPTLPEVTI AIVGEDDAGK TSFIKSALDL KGAPSPLTTK KKMSLDGLVY
IVRLLEIDLK RVTFDQDLNI VWPGSTKRST APRIDGVLLL HDATHPEKLE RTIELADDTT
VPCVLVACKC DQLPDSDEGE QGPIHERHKI YRTSPSSPRS QQMCIALVLR SIISNRAVTP
EQTSRLPHPP PAQSSPPPPP LRTTTKSFQP APLSADHRHS RANSETPTTV LSAAAGGAAT
SASDRTVDGN GAQRLPTDKI HPSDLAQQHA PGLPRNARSN SHPVRPQTPP TGARLNPRRP
SAQGDISPTR DHIHRRLQPA WRHSGGSDAF SSFLNMEDEM DGGAPPASPN ASLRPKPSSE
SNSSAEMGVT FDDLVDRLVA LPMSKQDSKF SAIFLCLYRK FAAPATLLNA LIGRFDKNES
SNVDQLARMA DQQRLLNVIA SWASEYPGDF AHPKTKKRIS DFVATLEKSH FYMFAAKEIG
SCLDSNAEDD DLGWAFSDGD VSETAPTETF FDNSGRSSPL PFTTETFEDE EGNDVEEDPI
YSTMHAMDLS EGPHDSTSRF SGTLSISSNN DKPSTTMSQS FTLLTIEAAQ KEALRLELTG
RTSLSKIQWR YFMDTSDEEF ARELTRMDWI MYNSFRPRDL VRHVSISGVD KDKIKSLQNV
NRMIKQFNHV AYFVASMILL RDKPKHRARC LEKFMSIAVK LRRQNNYNAL GAVIAAINGT
PVHRLTQTRE LIPVACQKEF MRLVILMSTS RSHSAYRLAW DNSFSERIPF LPLHRRDLVS
AEEGNKTFIG ENKSRINWKK FEVMGEVVIG IQRSQKCPHP QAQRYDDIER LILDCKLSGD
EEDLYARSLH LEPASGGEVS RKKFAWLPRA VYRALLRELP RSRASAPSPL HRRLRAVFRA
EGQTPSTPSA PTPSHISTVA STTPPAPFSL PSTAEEQALR IQEAEQFAQY ARAQRMYVEL
LERYNPGMNL EEEERIRLTA RRVGFDLPEL HDPAAVEKEQ KE
//
