ID S9PXP7_SCHOY Unreviewed; 3660 AA.
AC S9PXP7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Transcription-associated protein {ECO:0000313|EMBL:EPX72752.1};
GN ORFNames=SOCG_00514 {ECO:0000313|EMBL:EPX72752.1};
OS Schizosaccharomyces octosporus (strain yFS286) (Fission yeast)
OS (Octosporomyces octosporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=483514 {ECO:0000313|EMBL:EPX72752.1};
RN [1] {ECO:0000313|EMBL:EPX72752.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YFS286 {ECO:0000313|EMBL:EPX72752.1};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [2] {ECO:0000313|EMBL:EPX72752.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YFS286 {ECO:0000313|EMBL:EPX72752.1};
RG The Broad Institute Genome Sequencing Platform;
RA Nusbaum C., Russ C., Rhind N., Niki H., Allshire R., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Birren B.;
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE503207; EPX72752.1; -; Genomic_DNA.
DR RefSeq; XP_013018388.1; XM_013162934.1.
DR EnsemblFungi; EPX72752; EPX72752; SOCG_00514.
DR GeneID; 25029498; -.
DR VEuPathDB; FungiDB:SOCG_00514; -.
DR eggNOG; KOG0889; Eukaryota.
DR HOGENOM; CLU_000129_1_0_1; -.
DR OMA; NEWNQMQ; -.
DR OrthoDB; 2725516at2759; -.
DR Proteomes; UP000016088; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0004672; F:protein kinase activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:UniProt.
DR GO; GO:0019219; P:regulation of nucleobase-containing compound metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
FT DOMAIN 2488..3049
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3290..3630
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3628..3660
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3063..3114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3063..3111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3660 AA; 420064 MW; 36F2039A8C338DBE CRC64;
MGEDFRNTLE DSFESLKNDN VDISKKNEIL ASFNKEFPFS SVQNLGTIFS SWIPFLLEFV
QSFEVSFDSE STKNEIKRNT LSVLQQCTHK DEFQPYAELC VTRLIWFIRS ENDEIAIFCL
KIIMDVFKSF KGSIHSCSQS FFDLVVSLVR KLPSTIPFCF PKSSTMSSSV DEHSLLFTSA
PGSYLYKETL NLHQEVNHQS IGERNLQPAL QSFRVFIECP VVIVLILQVL RQSATSNVQL
LLPFLLDILQ IDVPIIDDLS IRVEQDSGFD FLRAVKNKST YRSVFMAQVK TLSFVAYILR
TFPETFTNKE VIPLIVVTLL RRCPHDMCFA RKELLVASRH ILSTNLRRLF ISVLDSLLDP
NILLGKGVAA RELLRPLAYS TLADLLHHIR NDISSEQIRK AITIYSHNLH DPSLSIGLQT
MGARLVLNMI DRIISLPNPT DSISLLFFIF DAFIEKFHEL NYKLQGRFQQ QNEKAVRRKD
GSAKFHMDEQ LPSIISMEKD GSFLFKNLML GLRALMYGLR MCKTRSFEAS NLHLNNIEKL
TTIQETHIFK KLFVEVAKGL SFFRPDEVYW EMYYAGNEDN LDKPLTSTLP KNKDEKDCLE
VFATIFIHLD PPLFIEIFES NLPMFFEQLK LNLTLFHIPQ FLLSNESTSP RFLNVLLRFL
LSKLEELGSA DERHGSVILR LFRLSFVTVS LFASKNEPVL RPYVSEIVIK CMKFAPNSKI
PLNYYLLLRA LFRGIGGGRF DSLYKEIMPL LHALLEAFNS LLASAKSQKE RDLFTELCLT
VPVRLSLLLP YLSYLMKPLV NSLKSGQELV NQGLRTFELF LDNLTPDFLD PIMAPVIDEL
MDALWSHLQP LPYSHQYSHN ALKILGKLGG RNRKLLKKIQ KMKVTSSSFR DFTMLVDIKG
TDRTQLLHYL NYVDPAVNIL TRQNLDLEIK RQSFNYLTTI TKIFFQQTSD IDNISSRIKA
SAQQLLRSNI PFKRPYSFAT NRGTSRDFIC KIDDDSVENT VLFHATYGLF IATSIEGLTD
TALRSLKALA ANILVYDLLY AIDLCKDGND ELPLYSHKEP VLSSYYFSHC LAKVMCEDDE
RIRNSVSHVL NFMFEFASLL FADSQHSYIL PIFEVLLSDF RHNCYDCQWH HKFGGCLGLK
YLIEQKCSSV WLFDRQADIL SALFFTLKDT TPEVPSICKT TVMDVLKCLF EKIYTTEDIK
IAPGVLGHLV LELSNHNSVV RNSTRELLSL LSSLSKISIS ELVSPYKERL LGPIFAKPLR
ALPFHIQIGH IDAVYYFISL EGHLLSLNEE VMRLIHETIA LAGADDDALI GHNKASHFKN
AAFLVRLRVV CINLLVSIIS KFDLTQGQHV HLRGKIISVF FKSLYVKSNE VIEAAFTGLQ
HALKDDQKLP KELLQTGLRP ILFNISDHKR LTVAGLEGLA RLLSLLTNYF KVEIGRKLLD
HLIALRDTVN LREISKMPLA SQTEMRIIQA LINIFHLLPN NANQYMQDLL QCVLDIEMKL
NRTCPNYFGI PLLKYVNRYP RDAWEFFYAR IDDSVCNNFL IELLRLEESE SFLLVVKENW
SVFRSILTTE VPTSSNTRYS FALEVSCEIF NRDPSFFKEK NSFFKGLTNA VEIIGDLINN
GGTISFITSW ERVLIQLCEF LLKIYDHCIK EFDSGLDLLG AFQSTEYYLS NTLMITLTKH
LQNSLSDNFE MKLRSLLFNF LSVNSSLQLK NTLLNDVLLQ YFHQHKGDNE SCQAWFHSLY
KLYLKGIFTK IGTSYDDGVS MGTLQIILFF LKNDYKVLEN YRQELVSLCC ALANSEDLII
KQLSLYSLSI FSSVFSFADN IPSLVYKALL KSPPVEVRHT VKVSFDYIFS SMSSSSELSN
RMVELPLQMM KSQSQNISQL LNVLDFLSSH VSYFYSYRSK YVSTIIDSLY KLGGIPNPNL
EIRSLSLNLV KMLVSWDQTE RTEQKTELFT NNQKRAILSF LFRFICLYSE LYTEGLCQEA
TLVLERLFSS KEWSNLGMKL TFFTKSIAHF DSTESNSIMY ANSLKTLSVV IKTADDTWIL
ENFSDLKLLM VQSLQNENSI VQPSLSNFVS SVLSLPIVRP SLINVPGISE IWSTISEWTE
RRLLAGSQLD VALSCLRCCL TGKKASANLL AAFMRSFHKV TKEVLSLGAQ EILATSMNMP
RESLKDEANS ILLSMIDLGC SRISDLEDQR RWFLSALVQI VEKSTNEQIC SSIFRAVCSW
VTNFENSVPT LKEKAALLLK MVSFENRFTS VNNSTLFSDY LYFIHDVFQM KEYEGSELLY
RLDAVYLLGT RSSDPKIRDL FISTLSTNLP KDVCSRFCKL LGEHHWDSLS NTYWIPQLNS
FLIDCFEFDR ICIFFNKPKR FPKLSLYLPS ESAKAELHSE DDKLKSALVT YQVLSDGISN
IKLSDIMIPV SKMQTVDSKM AGVLWEDLFN ASFSSFTSEQ VALASKAVIS ILSKEYHIRL
LGKTPNVLET FLNAILLSDK FIALPPQLLS FLSKNFGLHH QCILLLENAL RNTLGFRDDE
LVVYRNSCLD ALSEIYYGLD EHDLYIGLWK RRSRFLQTEI AASYEQCYKW DKAQMVYEQA
QINTCAGAIP YSPQENGFWH DHWIKSAQKL NQWDVLLDLS KQEGCDELYV ESAWRILDWK
TDRDKIEKQV KSLSPLVSLR RHTSDALLFL TSGDLKTNSV NEFTKIIHES MQFSLRRWQQ
LPKRIFQSHA PLLHHFQELA EMQEAYNIYV QLESTTAENL DSKLQEIKVI LQSWRERLPN
IWDDIDCWSD LVSWRKIVFK DINNVFLPLA SALQQAPNGT SNGNSTSYLY RGYHELAWII
NRFAHVARVQ HLPEVCISQL TKIYTLPNIE IQEAFLKLRE QAKCHYEYPS EMHLGLEVIN
NTNLMYFRNP QKAEFFTLKG MFQNSLGEYE EANQAFATAV QIDLSLGKAW AEWGLYHDNL
FSATPQDPWH ACNAVSCYLQ AASLYPSSKA KKYLSRLLWL LSTDVKGGIS AVINSFKSEI
PAWNWISFIP QLLASLSRSE AAHARAILIV IARTYPQALH FQLRTAYEDY TFANKQQVAA
STGAVSTSNG STESSAIEKA KDVNSGTSFS SSPSLTPGNE GSMSSEMNGK HSHSGARLPF
QITGDIMAIL KTAYPLLALT METMVDQIQS RLKSFPDEDA YRLIVALLND GLQYITRLGV
VTKSTPQLPM TKANIQRFAE NVLPTSVREA FFKDFVEQDL TLLAYVDKLR VWKKRFIEIL
DQRPKYLHLE QCSLYLSEFQ HQKFDEVEIP GQYLLDRDNN NDFVRLERFV PNVDLIRGHN
ICYKRLTMRG YDGILYPFAL QYPATRHSRR EERMHQLLRS INSILERKIE VQRRNITFNV
PISIPLSSHM RILSDDAANV TVQQINDRYC EEHGMASDHP IRFFFDKLQS NLIQLKHGNK
MHFEDSSLEE KKKVYRRRAL ALRMQILDTI KDSLIPETIY YGFFSKVYNN YSDFWFFKRA
FTVQYAYFLM TTYMFNIGSR FPHKVNINRS SGSISSADLL PLMTSNQPTF NNPEAVPFRL
TPPIQYLIGD IGVEGLLVGV LISFAQSFLS SDADIRQHLS LYIRDEVLWW HKQQKRSLPQ
GLQLFEMVRL NVELLSRRAT VISQNVPDNL PITQTLIDLI SQATNPKQLA QMDQLWQAWL
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