ID S9WZ56_CAMFR Unreviewed; 1763 AA.
AC S9WZ56;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 2-like protein {ECO:0000313|EMBL:EPY81363.1};
GN ORFNames=CB1_000743094 {ECO:0000313|EMBL:EPY81363.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY81363.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY81363.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KB017008; EPY81363.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 14.
DR Gene3D; 2.10.25.10; Laminin; 20.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF206; THROMBOMODULIN; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 17.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 19.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 12.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 26..58
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 353..396
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 523..575
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 684..726
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 727..763
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 770..809
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 941..981
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1077..1117
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1118..1159
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1160..1195
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1245..1286
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1353..1405
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1427..1469
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1470..1505
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1526..1578
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1675..1711
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1716..1760
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 65..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 30..40
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 48..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1474..1484
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1763 AA; 189861 MW; F5498C555FBDE09A CRC64;
MQLDGKCSLD MRKRLNKYVL NYTGPFPAVC QPPCQNRGSC SRPQLCVCRS GFRGARCEEV
IPEEEFDPQN ARPAPRRSAE GSPNLRRSSV ARESTTPRTR PPVPQPAAAS LPGPSPGVCV
PELFSDLGVA KKKLKAQISE QGDVTHRTLS GLSQTHPSQQ HVGLSQTVRL SPATAASGQL
TSNALPVGPG PERRDGAQQA AYLDHLSSPW GLNLTEKIKK IKIIFTPTIC KQTCARGHCA
NSCERGDTTT LYSQGGHGHD PKSGFRISSV NPSLVKVHIH HPPEASVQVH QVARVRGEAE
EAPEENSVET RPSPRLPASP GHGHWDSNSI PARSREAPRP PPPMVPRPQG LLGRCYLSAV
NGQCANPLLE LTAQEDCCGS VGAFWGVTSC APCPPRPASP VIENGQLQCP QGYKRLNLTH
CQGHPAKEQF PLVPKLDHLS APLFLCSVPT SPKPEQMALL ILGCHVLSPG PRDVNECLTL
GLCEDSECVN TRGSYLCTCR PGLMLDPSRS RCVSDKAISM QQGLCYRLLG PGTCALPLAQ
RITKQICCCS RVGKAWGSKC EKCPLPGTEA FREICPAGHG YTYSSSDIRL SMRKAEEEEL
ARPSREREQK SNGTLSRPVE RRPVERQPLR AATSTWLEAG TIPDKGDAVG RPTPPLPGQG
ILEAQEEEQV TTPMDVLVTP TPSAIDRCAT GATNICGPGT CVNLPDGYRC ICSPGYRLHP
SQAYCTDDNE CLRDPCKGRG RCVNHVGSYS CFCYPGYTLA TSGTTQECQD IDECEQPGVC
SDGRCTNTEG SYHCECNQGY VMVRKGHCQD ECTFPGVCPS GVCTNTAGSF SCRDCEEGYQ
PSALGHTCEG VRKTADLGAD EPLGHELQHA SEAPQLVEST ASCTRESPFL NFFHLSYVQD
NINECHHPGT CPDGRCVNSP GSYTCLACEE GYRGQSGSCV DVNECLAPGV CAHGTCTNLE
GSFRCSCEKG YEVTSDEKGC QDVDECASRT SCPTGLCLNT EGSFTCSACE SGYWVNEDGT
ACEEGLTSSE REARDLDECT FPGVCPSGVC TNTAGSFSCR DCEEGYQPSA LGHTCEDVDE
CEDLQSSCLG GECKNTAGSY QCLCPQGFQL ANGSVCEDIN ECAGEEYCAP RGECLNSHGS
FFCLCAPGFA SAEGGTSCQD VDECEVTDRC LGGQCVNTEG SFNCLCETGF QPSPESGACV
DIDECEDFRD TVCGAWSCEN SPGPYRCVLG CQPGFHVAPT RDCIDIDECA NDTVCGNHGF
CDNTDGSFRC LCDQGFETSP SGWDCIDVNE CELMLAVCGA ALCENVEGSF LCLCASDLEE
YDAQEGHCRP RVAGGQSIPE ASPEDHPPGP IRMECYSGQT GQPPCSSLLG RNTTQAECCC
TQGTGWGDAC DLCPAEDSVE FNEICPSGKG YVPVEGAWMF GQTTYTDADE CVIFGPGLCR
NGRCLNTVPG YICLCNPGYH YNAARRKCED HDECQDMACE DGECVNTEGS FHCFCSPPLT
LDLSQQRCVN STSGMEDLPD HDIHMDICWK KVTNYVCSHP LHGRRTTYTE CCCQDGEAWS
QQCALCPPRS SEVYAQLCNV ARIEAEREAG VHFRPGYEYG PGPEDLHYSL YGPDGAPFYN
YLGPEDAIPE PPFPNTASHR GDRIPVLEPP LPPSELQPRY VASHPEHQAG FEGLQAEECG
ILNGCENGRC VRVREGYTCD CFEGFQLDTA HMACVDVNEC DDLNGPAALC VHGHCENTEG
SYRCHCSPGY VAGAGPPHCT AKE
//
