ID S9X0S9_CAMFR Unreviewed; 722 AA.
AC S9X0S9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Insulin-degrading enzyme isoform 4 {ECO:0000313|EMBL:EPY81998.1};
GN ORFNames=CB1_000689015 {ECO:0000313|EMBL:EPY81998.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY81998.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY81998.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
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DR EMBL; KB016956; EPY81998.1; -; Genomic_DNA.
DR AlphaFoldDB; S9X0S9; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 5.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 10..60
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 200..457
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 461..644
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 722 AA; 84477 MW; E4E452E96E4E587E CRC64;
MTPDRWSVPV DWFAQFFLCP LFDESCKDRE VNAVDSEHEK NVMNDAWRLF QLEKATGNPK
HPFSKFGTGN KYTLETRPNQ EGIDVRQELL KFHSTYYSSN LMAICVLGRE SLDDLTNLVV
KLFSEVENKN VPLPEFPEHP FQEEHLKQLY KIVPIKDIRN LYVTFPIPDL QKYYKSNPGH
YLGHLIGHEG PGSLLSELKS KEEVLTAEYL LEEFRPDLIE MVLDKLRPEN VRVAIVSKSF
EGKTDRTEEW YGTQYKQEAI SDEVIKKWQN ADLNGKFKLP TKNEFIPTDF EILSLEKDAT
PYPSLIKDTA MSKLWFKQDD KFFLPKACLN FEFFSPFAYV DPLHCNMAYL YLELLKDSLN
EYAYAAELAG LSYDLQNTIY GMYLSVKGYN DKQPILLKKI IEKMATFEID EKRFEIIKEA
YMRSLNNFRA EQPHQHAMYY LRLLMTEVAW TKDELKEALD DVTLPRLKAF IPQLLSRLHI
EALLHGNITK QAALGIMQMV EDTLIEHAHT KPLLPSQLVR YREVQLPDRG WFVYQQRNEV
HNNCGIEIYY QTDMQSTSEN MFLELFCQII SEPCFNTLRT KEQLGYIVFS GPRRANGIQG
LRFIIQSEKP PHYLESRVEA FLIAMEKSIE DMTEEAFQKH IQALAIRRLD KPKKLSAECA
KYWGEIISQQ YNFDRDNTEV AYLKTLTKED IIKFYKVKNH SSALVQKLRR FLGEQALWLS
LD
//
