ID S9XAJ1_CAMFR Unreviewed; 1371 AA.
AC S9XAJ1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Toll-like receptor 9 {ECO:0000256|ARBA:ARBA00017400};
GN ORFNames=CB1_000460012 {ECO:0000313|EMBL:EPY84634.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY84634.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY84634.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-
CC like receptors) control host immune response against pathogens through
CC recognition of molecular patterns specific to microorganisms. TLR9 is a
CC nucleotide-sensing TLR which is activated by unmethylated cytidine-
CC phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. Upon CpG stimulation, induces B-cell
CC proliferation, activation, survival and antibody production.
CC {ECO:0000256|ARBA:ARBA00024895}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KB016744; EPY84634.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0002218; P:activation of innate immune response; IEA:UniProt.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd11284; ADF_Twf-C_like; 1.
DR CDD; cd11285; ADF_Twf-N_like; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.20.10; Severin; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR002108; ADF-H.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF3; TOLL-LIKE RECEPTOR 9; 1.
DR Pfam; PF00241; Cofilin_ADF; 2.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00102; ADF; 2.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 16.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51263; ADF_H; 2.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EPY84634.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 3..137
FT /note="ADF-H"
FT /evidence="ECO:0000259|PROSITE:PS51263"
FT DOMAIN 175..311
FT /note="ADF-H"
FT /evidence="ECO:0000259|PROSITE:PS51263"
FT DOMAIN 1206..1351
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT COILED 184..211
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1371 AA; 153613 MW; 2AB1ACDEE02A037F CRC64;
MFLVLLATEE LKEFFAKARA GSVRLIKVII EDEQLVLGAS RELVGCWDQD YDRAVLPLLD
AQQPCYLLYR LDTQNAQGFE WLFLAWSPDN SPVRLKMLYA ATRATVKKEF GGGHIKDELF
GTVKDDLSFA GYQKHLSSCA APAPLTSAER ELQQIRINEV KTEISVESKH QTLQGLAFPL
QPQAQRALQQ LRQKEINYIQ LKLDLERETI ELVHTEPTDV AQLPSRVPRD AARYHFFLYK
HTHEGDPLES VVFVYSMPGY KCSIKERMLY SSCKSRLLDS VEQDFQLEIA KKIEIGDGAE
LTAEFLYDEV HPKQHAFKQA FAKPKGPGGK RGHKRLIRGP GAQGIGRSCP AGSRNWTAAL
AAALAQGTLP AFLPCELQPH GLVNCNWLFL KSVPHFSAAA PRANITSLSL LSNRIHHLHN
SDFAHLSSLR SLNLKWNCPP AGLSPMHFPC HMTIEPNTFL AVPTLEELNL SYNSITTVPA
LPSSLVSLSL SRTSILVLDP THLAGLHALR FLYMDGNCYY KNPCPRALEV APGALLGLGN
LTHLSLKYNN LTEVPRRLPP SLESLLLSYN HIVTLAPEDL ANLTALRVLD VGGNCRRCDH
ARNPCIECPK GFPKLHPDTF SHLSRLEGLV LKDSSLYRLD TRWFRGLGSL RVLDLSENFL
YTCITKTTAF QGLARLTKLN LSFNYHKKVS FAHLHLASSF RGLLSLKELD MHGIFFRSLS
ETTLQPLAHL PKLQTLHLQM NFINQAQLSI FEAFPGLLYV DLSDNRISGA MRPAATTGKA
DGRGKLRLPT RNLAQGPLNT LGSEDFMPNC KPFSFTLDLS RNNLVTVQPE MFAHLSRLQC
LRLSHNSISQ AVNGSQFVPL TSLRVLDLSH NKLDLYHGRS FTELPRLEAL DLSYNSQPFS
MQGVGHNLSF VAQLPALRYL SLAHNGIHSR VSQQLCSASV RALDFSGNAL SQMWAEGDLY
LHFFQGLRSL VLLDLSQNHL HTLLPRNLDN LPKSLRLLRL RDNKLAFFNW SSLALLPELE
ALDLAGNQLK ALSNGSLPSS TQLRRLDLSG NSITFVAPGF FALAKVLQEL NLSANALRTV
EPSWFGSLVG TLKILDVSAN PLHCACGAVF VDFLLEVQAA VPGLPSRVKC GSPGQLRGRS
IFAQDLRLCL DEALSWGCFG LSLLTVALGL AVPMLYHLCG WDLWYCFHLC LAWLPRRGQR
RGADTLLYDA FVVFDKAQSA VADWVYNELR VQLEERRGRR ALRLCLEERD WLPGKTLFEN
LWASIYSSRK TLFVLAHTDR VSGLLRASFL LAQQRLLEDR KDVVVLVILR PDAYRSRYVR
LRQHLCRQSV LLWPQQPSGQ GSFWAQLGMT LTRDNRHFYN QNFCRGPTTA G
//
