ID S9XYS3_CAMFR Unreviewed; 1148 AA.
AC S9XYS3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=CB1_000843022 {ECO:0000313|EMBL:EPY80326.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY80326.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY80326.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KB017094; EPY80326.1; -; Genomic_DNA.
DR AlphaFoldDB; S9XYS3; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF00855; PWWP; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 1..55
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 56..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1148 AA; 130033 MW; D3BB260A152AB13D CRC64;
MEGYPWWPCL VYNHPFDGTF IREKGKSARI HVQFFDDSPT RGWVSRRLLK PYTGATYASD
KSEEENEIES EEEVQPKVQG SRRSSRQIKK RRVISDSESD IGGSDVEFKP DAKEEGSSDE
ISSGVGDSDS EGLDSPVKVA PKRKRMITGN GSLKRKSSRK EMPSATKRAT GISSETKSTL
SAFSAPQNSE SQTHTSGGCD DSSRPTVWYH ETLEWLKEEK RRDVHRRRPD HPDFDASTLY
VPEDFLNSCT PGMRKWWQIK SQNFDLVIFY KVGKFYELYH MDALTGVNEL GLVFMKGNWA
HSGFPEIAFG RYSDSLVQKG YKVARVEQTE TPEMMEARCR KMAHISKYDR VVRREICRVI
TKGTQTYSVL EGDPSENYSK YLLSLKEKEE DSSGHTRVYG VCFVDTSLGK FFIGQFSDDR
HCSRFRTLVA HYPPVQVLFE KGNLSTETKM ILKGSLSSSL QESLMPGSQF WDAAKTLRTL
VEEGYFTDNL NEGSGVMLPQ VLKAMTSESD SIGLTPGEKS ELALSALGGC VFYLKKCLID
QELLSMANFE EYVPLDSDMV SATRPGAFFA KANQRMVLDA VTLNNLEIFL NGTNGSTEGT
LLEKIDTCHT PFGKRLLKQW LCAPLCNPYA INDRLDAIED LMIVPDKTSE VADLLKKLPD
LERLLSKIHN VGSPLKSQNH PDSRAIMYEE TTYSKKKIID FLSALEGFKV ICKIVEIMEE
VVDDFKSKIL KQIITLQTKT PEGRFPDLTV ELNRWATAFD HEKARKTGLI TPKAGFDPDY
DQALADIREN EQSLLEYLEK QRSRIGCRTI VYWGIGRNRY QLEIPENFIT RNLPEEYELK
STKKGCKRYW TKTIEKKLAS LINAEERRDV SLKDCMRRLF YNFDKNYKDW QAAVECIAVL
DVLLCLANYS RGGDGPMCRP VILLPEEDTP PFLDLKGSRH PCITKTFFGD DFIPNDILIG
CKEEEEENGQ AYCVLVTGPN MGGKSTLMRQ AGLLAVMAQM GCYVPAEVCR LTPIDRVFTR
LGASDRIMSG RGTATFDGTA IANAVVKELA ENIKCRTLFS THYHSLVEDY SQNVAVRLGH
MACMVENECE DPSQETITFL YKFIKGACPK SYGFNAARLA NLPEEVIRKG HRKAREFEKM
TQSLRLFR
//
