ID SDA1_BOVIN Reviewed; 688 AA.
AC A5D7C2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=Protein SDA1 homolog;
DE AltName: Full=SDA1 domain-containing protein 1;
GN Name=SDAD1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hippocampus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC cytoplasm. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000305}.
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DR EMBL; BC140502; AAI40503.1; -; mRNA.
DR RefSeq; NP_001095959.1; NM_001102489.1.
DR AlphaFoldDB; A5D7C2; -.
DR SMR; A5D7C2; -.
DR STRING; 9913.ENSBTAP00000007240; -.
DR PaxDb; 9913-ENSBTAP00000007240; -.
DR GeneID; 507675; -.
DR KEGG; bta:507675; -.
DR CTD; 55153; -.
DR eggNOG; KOG2229; Eukaryota.
DR InParanoid; A5D7C2; -.
DR OrthoDB; 5482564at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027312; Sda1.
DR InterPro; IPR048292; SDA1_C.
DR InterPro; IPR007949; SDA1_MD.
DR InterPro; IPR012977; SDA1_N.
DR PANTHER; PTHR12730; HSDA/SDA1-RELATED; 1.
DR PANTHER; PTHR12730:SF0; PROTEIN SDA1 HOMOLOG; 1.
DR Pfam; PF21638; SDA1_C; 1.
DR Pfam; PF05285; SDA1_dom; 1.
DR Pfam; PF08158; SDA1_HEAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Nucleus; Phosphoprotein; Protein transport;
KW Reference proteome; Ribosome biogenesis; Transport.
FT CHAIN 1..688
FT /note="Protein SDA1 homolog"
FT /id="PRO_0000328430"
FT REGION 484..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 254..318
FT /evidence="ECO:0000255"
FT COMPBIAS 484..509
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 232
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVU7"
FT MOD_RES 234
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVU7"
FT MOD_RES 236
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVU7"
FT MOD_RES 586
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVU7"
FT MOD_RES 596
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVU7"
SQ SEQUENCE 688 AA; 79813 MW; B419E955D34DCB9E CRC64;
MSSRNNNKLP SNLPQLQNLI KRDPPAYVEE FLQQYNHYKS NVEIFKLQPN KPSKELAELV
MFMAQISHCY PEHLSNFPQE LKDLLSYNHT VLDPDLRMTF CKALILLRNK NLINPSSLLE
LFFELLRCHD KLLRKTLYTH IVTDIKNINA KHKNNKVNIV LQNFMYTMLR DSNATAAKIS
LDVMIELYRR NIWNDAKTVN VITTACFSKV TKILVAALTF FLGKDEEEKQ DSDSESEDEG
PTARDLLVQY ATGKKSSKNK KKLEKAMKVL TKHKKKKKPE VFNFSAIHLI HDPQDFAEKL
LKQLESSKER FEVKMMLMNL ISRLVGIHEL FLFNFYPFVQ RFLQPHQREV TKILLFAAQA
SHHLVPPEII QSLLMTVANN FVTDKNSGEV MTVGINAIKE ITARCPLAMT EELLQDLAQY
KTHKDKNVMM SARTLIQLFR TLNPQMLQKK FRGKPTEASI EARVQEYGEL DAKDYIPGAE
ILEVENEEEN AEGDEDGWES ASLSDEADSD GEWVDVHHSS DEEQKEISEK LNSMPLEERK
AKAAAVSTSR VLSQEDFQKI RMAQMRKELD AAPGKAQKRK YIEIDSDEER RGELLSLRDI
ERLHKKPKSD KETRLATAMA GKTDRKEFVR KKTKMNPFSS STNKEKKKQK NFMMMRYSHN
VRSKNKRSFR EKQLALRDAL LKKRKRMK
//
