ID SFH11_ARATH Reviewed; 376 AA.
AC F4JYJ3; Q9FGK6;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein SFH11;
DE AltName: Full=Protein SEC FOURTEEN HOMOLOGS 11;
DE Short=AtSFH11;
GN Name=SFH11; OrderedLocusNames=At5g47510; ORFNames=MNJ7.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=15728190; DOI=10.1083/jcb.200412074;
RA Vincent P., Chua M., Nogue F., Fairbrother A., Mekeel H., Xu Y., Allen N.,
RA Bibikova T.N., Gilroy S., Bankaitis V.A.;
RT "A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes
RT membrane growth of Arabidopsis thaliana root hairs.";
RL J. Cell Biol. 168:801-812(2005).
RN [4]
RP REVIEW.
RX PubMed=17051233; DOI=10.1038/nchembio835;
RA Ile K.E., Schaaf G., Bankaitis V.A.;
RT "Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid
RT signaling.";
RL Nat. Chem. Biol. 2:576-583(2006).
CC -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC complex. Catalyzes the transfer of phosphatidylinositol and
CC phosphatidylcholine between membranes in vitro (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SFH family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09077.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB025628; BAB09077.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED95527.1; -; Genomic_DNA.
DR RefSeq; NP_199562.2; NM_124124.3.
DR AlphaFoldDB; F4JYJ3; -.
DR SMR; F4JYJ3; -.
DR STRING; 3702.F4JYJ3; -.
DR PaxDb; 3702-AT5G47510-1; -.
DR ProteomicsDB; 234553; -.
DR EnsemblPlants; AT5G47510.1; AT5G47510.1; AT5G47510.
DR GeneID; 834801; -.
DR Gramene; AT5G47510.1; AT5G47510.1; AT5G47510.
DR KEGG; ath:AT5G47510; -.
DR Araport; AT5G47510; -.
DR TAIR; AT5G47510; -.
DR eggNOG; KOG1471; Eukaryota.
DR HOGENOM; CLU_014001_6_1_1; -.
DR InParanoid; F4JYJ3; -.
DR PRO; PR:F4JYJ3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4JYJ3; baseline and differential.
DR Genevisible; F4JYJ3; AT.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.10.8.20; N-terminal domain of phosphatidylinositol transfer protein sec14p; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR PANTHER; PTHR45657; CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED; 1.
DR PANTHER; PTHR45657:SF50; PHOSPHATIDYLINOSITOL_PHOSPHATIDYLCHOLINE TRANSFER PROTEIN SFH11; 1.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF46938; CRAL/TRIO N-terminal domain; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 3: Inferred from homology;
KW Cell membrane; Coiled coil; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..376
FT /note="Phosphatidylinositol/phosphatidylcholine transfer
FT protein SFH11"
FT /id="PRO_0000423471"
FT DOMAIN 92..266
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 323..357
FT /evidence="ECO:0000255"
SQ SEQUENCE 376 AA; 42935 MW; B9813B434620A97B CRC64;
MQETDRDIHI SDGTMNKEEQ SPNNEEMVEA FRNLLLLHGH LPDKHGDHNT LRRFLKMRDF
DLEKSKEAFL NYMKWRVDYK VDLISQKFKF EEYGEVKKHY PHGFHKVDKT GRPIYIERLG
MTDLNAFLKA TTIERYVNYH IKEQEKTMSL RYPACSIASD KHVSSTTTIL DVSGVGMSNF
SKPARSLFME IQKIDSNYYP ETLHRLFVVN ASSGFRMLWL ALKTFLDART LAKVQVLGPN
YLGELLEAIE PSNLPTFLGG NCTCSDHGGC LFSDEGPWND PGIKEKIEEP STIEDAHSET
MDKVSENAPA NQKESLGEVM ITMEKYAALK TAVKDSQKRI EMLEISLHET KKVLNGLAEI
IEAIQPNQPI TKCKPV
//
