ID SLYA_ECO45 Reviewed; 144 AA.
AC B7M9Z6;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Transcriptional regulator SlyA {ECO:0000255|HAMAP-Rule:MF_01819};
GN Name=slyA {ECO:0000255|HAMAP-Rule:MF_01819}; OrderedLocusNames=ECS88_1690;
OS Escherichia coli O45:K1 (strain S88 / ExPEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585035;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S88 / ExPEC;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Transcription regulator that can specifically activate or
CC repress expression of target genes. {ECO:0000255|HAMAP-Rule:MF_01819}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01819}.
CC -!- SIMILARITY: Belongs to the SlyA family. {ECO:0000255|HAMAP-
CC Rule:MF_01819}.
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DR EMBL; CU928161; CAR03003.1; -; Genomic_DNA.
DR RefSeq; WP_000445640.1; NC_011742.1.
DR AlphaFoldDB; B7M9Z6; -.
DR SMR; B7M9Z6; -.
DR KEGG; ecz:ECS88_1690; -.
DR HOGENOM; CLU_083287_18_2_6; -.
DR Proteomes; UP000000747; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01819; HTH_type_SlyA; 1.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR039422; MarR/SlyA-like.
DR InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR InterPro; IPR023071; Tscrpt_reg_SlyA.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33164:SF64; TRANSCRIPTIONAL REGULATOR SLYA; 1.
DR PANTHER; PTHR33164; TRANSCRIPTIONAL REGULATOR, MARR FAMILY; 1.
DR Pfam; PF01047; MarR; 1.
DR PRINTS; PR00598; HTHMARR.
DR SMART; SM00347; HTH_MARR; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01117; HTH_MARR_1; 1.
DR PROSITE; PS50995; HTH_MARR_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..144
FT /note="Transcriptional regulator SlyA"
FT /id="PRO_1000188006"
FT DOMAIN 2..135
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
FT DNA_BIND 49..72
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
SQ SEQUENCE 144 AA; 16380 MW; B61E43A45BEF6CAB CRC64;
MESPLGSDLA RLVRIWRALI DHRLKPLELT QTHWVTLHNI HQLPPDQSQI QLAKAIGIEQ
PSLVRTLDQL EEKGLISRQT CASDRRAKRI KLTEKAEPLI SEMEAVINKT RAEILHGISA
EELEQLIKLI AKLEHNIIEL QAKG
//
