ID SRCA_CHICK Reviewed; 472 AA.
AC Q90577; A0A1D5P984; A0A1D5PLW0;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Sarcalumenin {ECO:0000250|UniProtKB:P13666};
DE Flags: Precursor;
GN Name=SRL;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Anterior latissimus dorsi muscle;
RA Boyd K.L., Kutchai H., Takeyasu K.;
RT "Molecular cloning of the 53kDa glycoprotein from chicken sarcoplasmic
RT reticulum.";
RL Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|Proteomes:UP000000539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl {ECO:0000312|Proteomes:UP000000539};
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
CC -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen
CC {ECO:0000250|UniProtKB:P13666}. Sarcoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P13666}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P13666}. Note=May associate with the
CC sarcoplasmic reticulum membrane, via a calcium-dependent mechanism.
CC {ECO:0000250|UniProtKB:P13666}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=53 kDa {ECO:0000303|Ref.1};
CC IsoId=Q90577-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q90577-2; Sequence=VSP_060760, VSP_060761;
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:P13666}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC ProRule:PRU01055}.
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DR EMBL; Z21720; CAA79817.1; -; mRNA.
DR EMBL; AADN05000376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; S45068; S45068.
DR RefSeq; NP_990660.1; NM_205329.1. [Q90577-1]
DR AlphaFoldDB; Q90577; -.
DR SMR; Q90577; -.
DR STRING; 9031.ENSGALP00000053831; -.
DR GlyCosmos; Q90577; 3 sites, No reported glycans.
DR PaxDb; 9031-ENSGALP00000038763; -.
DR GeneID; 396269; -.
DR KEGG; gga:396269; -.
DR CTD; 6345; -.
DR VEuPathDB; HostDB:geneid_396269; -.
DR eggNOG; KOG1954; Eukaryota.
DR InParanoid; Q90577; -.
DR PhylomeDB; Q90577; -.
DR PRO; PR:Q90577; -.
DR Proteomes; UP000000539; Chromosome 14.
DR Bgee; ENSGALG00000038884; Expressed in skeletal muscle tissue and 6 other cell types or tissues.
DR GO; GO:0033018; C:sarcoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR CDD; cd09913; EHD; 1.
DR Gene3D; 1.10.268.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR031692; EHD_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR43681:SF1; SARCALUMENIN; 1.
DR PANTHER; PTHR43681; TRANSMEMBRANE GTPASE FZO; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF16880; EHD_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Sarcoplasmic reticulum; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..472
FT /note="Sarcalumenin"
FT /id="PRO_0000045428"
FT DOMAIN 89..330
FT /note="Dynamin-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 99..106
FT /note="G1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 127..128
FT /note="G2 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 189..192
FT /note="G3 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 254..257
FT /note="G4 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 278
FT /note="G5 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT CARBOHYD 280
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 388
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 20
FT /note="A -> ADEDVGRAAQRPSSEALPHVEEMAANGSPEEEEEDGGAANTSVLRTA
FT EGGGEREEELKGGLSEAAGQGQEGPDGASGKDAMLGGPGAEGEAAPEPGTQHGGQEEEE
FT ANTKEVASEEKEMEEPRVSAPEGGEEEDEQSSEEDDEQEESEEDEGKAESEEEGKSAEE
FT GESEEDGASPEVLEDGAEGTDMKETPGENSHGKAAASSEGEQRDGPASCHHPPCGDVEP
FT SPGSSSQAAAEEPSTAVEEAAATEDPPTAVKIPPAALENPPTAEDPPAAVGDPPADQAP
FT LAEMENPASPSARHAAAEPRRSQI (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_060760"
FT VAR_SEQ 84
FT /note="I -> ITAYPGRTLGSSA (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_060761"
FT CONFLICT 127
FT /note="E -> G (in Ref. 1; CAA79817)"
FT CONFLICT 162
FT /note="E -> K (in Ref. 1; CAA79817)"
FT CONFLICT 177
FT /note="V -> L (in Ref. 1; CAA79817)"
FT CONFLICT 270
FT /note="Missing (in Ref. 1; CAA79817)"
FT CONFLICT 396
FT /note="N -> Q (in Ref. 1; CAA79817)"
FT CARBOHYD Q90577-2:59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 472 AA; 54264 MW; 1A8F45D8D49DA7D6 CRC64;
MKRLNLLCCC VASLLLLGTA EEVEDASEPT KRDRSHLENT LKLNEDKPAD DFSGVLQRLR
KIYHASIKPL EQSYRYNELR QHEITDGEIT SKPMVLFLGP WSVGKSSMIN YLLGLDDTPY
QLYTGAEPTT SEFTVIMHGP KLKTIEGIVM AADSARSFSP LEKFGQNFLE KLIGIEVPHK
LLERVTFVDT PGIIENRKQQ ERGYPFNDVC QWFIDRADLI FVVFDPTKLD VGLELEMLFR
QLKGRESQIR IILNKADSLA TQELMRVYGA LFWSLAPLIN VTEPPRVYVS SFWPHEYHPD
THKDLFLKEE ISLLEDLNQV IENRMENKIA FIRQHAIRVR IHALLVDRYL QTYKDKMTFF
SDGELVFRDI VEDPDKFFIF KSILAKTNVS KFDLPNREAY KDFFGINPIT SFKLLSQQCS
YMGGCYLEKI EKAITRELPD LLGSIGLGKK PNVLSCDVTG CGETPKNRYK KP
//
