ID ST4A1_RAT Reviewed; 284 AA.
AC P63047; O88872; Q91XS5; Q9CWY7; Q9DC97;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=Sulfotransferase 4A1;
DE Short=ST4A1;
DE EC=2.8.2.-;
DE AltName: Full=Brain sulfotransferase-like protein;
DE Short=rBR-STL;
DE AltName: Full=Nervous system sulfotransferase;
DE Short=NST;
GN Name=Sult4a1; Synonyms=Sultx3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP SUBCELLULAR LOCATION.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=10698717; DOI=10.1042/bj3460857;
RA Falany C.N., Xie X., Wang J., Ferrer J., Falany J.L.;
RT "Molecular cloning and expression of novel sulphotransferase-like cDNAs
RT from human and rat brain.";
RL Biochem. J. 346:857-864(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 125-284.
RC TISSUE=Brain;
RA Martin S.C., Farb D.H.;
RT "Molecular identification of a rat nervous system cytoplasmic
RT sulfotransferase, NST.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8 AND THR-11, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Atypical sulfotransferase family member with very low
CC affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low
CC catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-
CC nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in
CC the metabolism of drugs and neurotransmitters in the CNS (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10698717}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain, not detected in the liver,
CC kidney, spleen, heart, small intestine or testis.
CC {ECO:0000269|PubMed:10698717}.
CC -!- DEVELOPMENTAL STAGE: Expressed at low levels in brains of 1-day old
CC animals but increase to adult levels from 7-day old animals and remain
CC at that level in adults. {ECO:0000269|PubMed:10698717}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. {ECO:0000305}.
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DR EMBL; AF188699; AAF61198.1; -; mRNA.
DR EMBL; AF176343; AAK64596.1; -; mRNA.
DR RefSeq; NP_113829.1; NM_031641.1.
DR AlphaFoldDB; P63047; -.
DR SMR; P63047; -.
DR STRING; 10116.ENSRNOP00000066760; -.
DR iPTMnet; P63047; -.
DR PhosphoSitePlus; P63047; -.
DR PaxDb; 10116-ENSRNOP00000066760; -.
DR Ensembl; ENSRNOT00000075099.3; ENSRNOP00000066760.1; ENSRNOG00000046975.3.
DR Ensembl; ENSRNOT00055051543; ENSRNOP00055042487; ENSRNOG00055029751.
DR Ensembl; ENSRNOT00060050278; ENSRNOP00060041890; ENSRNOG00060028924.
DR Ensembl; ENSRNOT00065052501; ENSRNOP00065043148; ENSRNOG00065030451.
DR GeneID; 58953; -.
DR KEGG; rno:58953; -.
DR AGR; RGD:69292; -.
DR CTD; 25830; -.
DR RGD; 69292; Sult4a1.
DR eggNOG; KOG1584; Eukaryota.
DR GeneTree; ENSGT00940000158662; -.
DR HOGENOM; CLU_027239_1_1_1; -.
DR InParanoid; P63047; -.
DR OMA; MVESCHQ; -.
DR OrthoDB; 3083090at2759; -.
DR PhylomeDB; P63047; -.
DR Reactome; R-RNO-156584; Cytosolic sulfonation of small molecules.
DR PRO; PR:P63047; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000046975; Expressed in frontal cortex and 11 other cell types or tissues.
DR Genevisible; P63047; RN.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0008146; F:sulfotransferase activity; ISO:RGD.
DR GO; GO:0140059; P:dendrite arborization; IMP:UniProtKB.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0051923; P:sulfation; IBA:GO_Central.
DR GO; GO:0006790; P:sulfur compound metabolic process; ISO:RGD.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR11783:SF274; SULFOTRANSFERASE 4A1; 1.
DR PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Lipid metabolism; Phosphoprotein; Reference proteome;
KW Steroid metabolism; Transferase.
FT CHAIN 1..284
FT /note="Sulfotransferase 4A1"
FT /id="PRO_0000085169"
FT MOD_RES 8
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 11
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 205
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9BR01"
SQ SEQUENCE 284 AA; 33054 MW; FCAE940F7219E6FC CRC64;
MAESEAETPG TPGEFESKYF EFHGVRLPPF CRGKMEDIAD FPVRPSDVWI VTYPKSGTSL
LQEVVYLVSQ GADPDEIGLM NIDEQLPVLE YPQPGLDIIK ELTSPRLIKS HLPYRFLPSD
LHNGDSKVIY MARNPKDLVV SYYQFHRSLR TMSYRGTFQE FCRRFMNDKL GYGSWFEHVQ
EFWEHRMDAN VLFLKYEDMH RDLVTMVEQL ARFLGVSCDK AQLESLIEHC HQLVDQCCNA
EALPVGRGRV GLWKDIFTVS MNEKFDLVYK QKMGKCDLTF DFYL
//
