ID STX1A_CAEBR Reviewed; 293 AA.
AC A8WVD0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE RecName: Full=Syntaxin-1A;
DE AltName: Full=Uncoordinated protein 64;
GN Name=unc-64 {ECO:0000312|WormBase:CBG03570};
GN ORFNames=CBG03570 {ECO:0000312|WormBase:CBG03570};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Plays a critical role in several secretory processes,
CC including cuticle secretion and neurotransmitter release, and probably
CC assists in neuronal membrane maturation or the final stages of neuronal
CC differentiation (By similarity). Plays a role in synaptic vesicle
CC docking and tethering through its association with unc-18 (By
CC similarity). Through binding to unc-18 mediates the release of the
CC neurotransmitter acetylcholine from cholinergic motor neurons, and
CC thereby promotes locomotory behaviors (By similarity). Essential for
CC embryonic viability and development (By similarity). Has a role in
CC dauer formation and adult life span. Required for locomotion (By
CC similarity). Probably by regulating neuronal transmission downstream of
CC lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of
CC innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in
CC pharyngeal pumping during the quiescent state that precedes each larval
CC molt (By similarity). {ECO:0000250|UniProtKB:O16000}.
CC -!- SUBUNIT: Interacts (via N-terminus, in open or in closed conformation)
CC with unc-18; the interaction is direct (By similarity). Interaction in
CC open conformation with unc-18 promotes synaptic vesicle docking and
CC tethering (By similarity). Interaction via N-terminus with unc-18
CC mediates the secretion of the neurotransmitter acetylcholine from
CC cholinergic motor neurons (By similarity). Interaction with unc-18 is
CC reduced in the presence of unc-13 (By similarity).
CC {ECO:0000250|UniProtKB:O16000}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O16000};
CC Single-pass type IV membrane protein {ECO:0000305}. Cell projection,
CC axon {ECO:0000250|UniProtKB:O16000}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:O16000}. Perikaryon
CC {ECO:0000250|UniProtKB:O16000}.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR EMBL; HE601339; CAP24441.1; -; Genomic_DNA.
DR RefSeq; XP_002647050.1; XM_002647004.1.
DR AlphaFoldDB; A8WVD0; -.
DR SMR; A8WVD0; -.
DR STRING; 6238.A8WVD0; -.
DR EnsemblMetazoa; CBG03570.1; CBG03570.1; WBGene00026410.
DR GeneID; 8589049; -.
DR KEGG; cbr:CBG_03570; -.
DR CTD; 8589049; -.
DR WormBase; CBG03570; CBP06543; WBGene00026410; Cbr-unc-64.
DR eggNOG; KOG0810; Eukaryota.
DR HOGENOM; CLU_042423_2_2_1; -.
DR InParanoid; A8WVD0; -.
DR OMA; RWICFIL; -.
DR OrthoDB; 2876074at2759; -.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:EnsemblMetazoa.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; ISS:UniProtKB.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0040011; P:locomotion; ISS:UniProtKB.
DR GO; GO:0007269; P:neurotransmitter secretion; ISS:UniProtKB.
DR GO; GO:1905488; P:positive regulation of anterior/posterior axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
DR GO; GO:0007271; P:synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0007419; P:ventral cord development; IEA:EnsemblMetazoa.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR CDD; cd15880; SNARE_syntaxin1; 1.
DR CDD; cd00179; SynN; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 1.20.58.70; -; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; SYNTAXIN; 1.
DR PANTHER; PTHR19957:SF307; SYNTAXIN-1A; 1.
DR Pfam; PF05739; SNARE; 1.
DR Pfam; PF00804; Syntaxin; 1.
DR SMART; SM00503; SynN; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; t-snare proteins; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Coiled coil; Cuticle;
KW Developmental protein; Differentiation; Membrane; Neurogenesis;
KW Neurotransmitter transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..293
FT /note="Syntaxin-1A"
FT /id="PRO_0000314060"
FT TOPO_DOM 1..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..293
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 195..257
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT COILED 69..95
FT /evidence="ECO:0000255"
SQ SEQUENCE 293 AA; 33576 MW; E004BF31D9F73B03 CRC64;
MTKDRLAALK AAQSEDEQDD DMHMETGNAQ YMEEFFEQVE EIRGSVDIIA NNVEEVKKKH
SAILSNPVND QKTKEELDEL MAVIKRAANK VRGKLKLIEN AIEHDENQQG AGNADLRIRK
TQHSTLSRRF VEVMTDYNKT QTDYRERCKG RIQRQLDIAG KQVGDEDLEE MIESGNPGVF
TQGIITDTQQ AKQTLADIEA RHNDIMKLES SIRELHDMFM DMAMLVESQG EMVDRIEYNV
EHAKEFVDRA VADTKKAVQY QSKARRKKII ILIVVTVIIV ILSLWLIQYI PGI
//
