ID STX3_RAT Reviewed; 289 AA.
AC Q08849;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 24-JAN-2024, entry version 162.
DE RecName: Full=Syntaxin-3;
GN Name=Stx3; Synonyms=Stx3a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7690687; DOI=10.1016/0092-8674(93)90466-4;
RA Bennett M.K., Garcia-Arraras J.E., Elferink L.A., Peterson K.E.,
RA Fleming A.M., Hazuka C.D., Scheller R.H.;
RT "The syntaxin family of vesicular transport receptors.";
RL Cell 74:863-873(1993).
CC -!- FUNCTION: Potentially involved in docking of synaptic vesicles at
CC presynaptic active zones. Apical receptor involved in membrane fusion
CC of apical vesicles. Essential for survival of retinal photoreceetors.
CC {ECO:0000250|UniProtKB:Q13277}.
CC -!- SUBUNIT: Interacts with REEP6 (By similarity). Interacts with PRPH2 in
CC rod and cone photoreceptors (By similarity). Interacts with ROM1 (By
CC similarity). Interacts with SNAP25 (By similarity). Interacts with
CC VAMP2 (By similarity). {ECO:0000250|UniProtKB:Q64704}.
CC -!- INTERACTION:
CC Q08849; P60881: Snap25; NbExp=4; IntAct=EBI-8311156, EBI-1027214;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC membrane protein {ECO:0000305}. Note=Localized to the inner and outer
CC plexiform layers, the cell body and the inner segments of
CC photoreceptors. {ECO:0000250|UniProtKB:Q64704}.
CC -!- TISSUE SPECIFICITY: Heart, spleen, lung and kidney.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR EMBL; L20820; AAA03045.1; -; mRNA.
DR PIR; D48213; D48213.
DR RefSeq; NP_112386.1; NM_031124.1.
DR RefSeq; XP_017445263.1; XM_017589774.1.
DR AlphaFoldDB; Q08849; -.
DR SMR; Q08849; -.
DR BioGRID; 249660; 3.
DR CORUM; Q08849; -.
DR IntAct; Q08849; 3.
DR MINT; Q08849; -.
DR STRING; 10116.ENSRNOP00000028535; -.
DR iPTMnet; Q08849; -.
DR PhosphoSitePlus; Q08849; -.
DR PaxDb; 10116-ENSRNOP00000028535; -.
DR Ensembl; ENSRNOT00000028535.6; ENSRNOP00000028535.4; ENSRNOG00000021013.8.
DR Ensembl; ENSRNOT00055030101; ENSRNOP00055024178; ENSRNOG00055017785.
DR Ensembl; ENSRNOT00060052152; ENSRNOP00060043376; ENSRNOG00060029880.
DR Ensembl; ENSRNOT00065038371; ENSRNOP00065031081; ENSRNOG00065022397.
DR GeneID; 81802; -.
DR KEGG; rno:81802; -.
DR UCSC; RGD:621005; rat.
DR AGR; RGD:621005; -.
DR CTD; 6809; -.
DR RGD; 621005; Stx3.
DR eggNOG; KOG0810; Eukaryota.
DR GeneTree; ENSGT01030000234627; -.
DR HOGENOM; CLU_042423_2_2_1; -.
DR InParanoid; Q08849; -.
DR OrthoDB; 2876074at2759; -.
DR PhylomeDB; Q08849; -.
DR TreeFam; TF313763; -.
DR Reactome; R-RNO-449836; Other interleukin signaling.
DR PRO; PR:Q08849; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000021013; Expressed in duodenum and 17 other cell types or tissues.
DR ExpressionAtlas; Q08849; baseline and differential.
DR Genevisible; Q08849; RN.
DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR GO; GO:0042582; C:azurophil granule; ISO:RGD.
DR GO; GO:0005911; C:cell-cell junction; ISO:RGD.
DR GO; GO:0030425; C:dendrite; ISO:RGD.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR GO; GO:0030426; C:growth cone; IDA:HGNC-UCL.
DR GO; GO:0030027; C:lamellipodium; ISO:RGD.
DR GO; GO:0042470; C:melanosome; ISO:RGD.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0043005; C:neuron projection; IDA:HGNC-UCL.
DR GO; GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
DR GO; GO:0001750; C:photoreceptor outer segment; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:BHF-UCL.
DR GO; GO:0098794; C:postsynapse; ISO:RGD.
DR GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0042734; C:presynaptic membrane; ISO:RGD.
DR GO; GO:0097470; C:ribbon synapse; ISO:RGD.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; ISO:RGD.
DR GO; GO:0030141; C:secretory granule; ISO:RGD.
DR GO; GO:0031201; C:SNARE complex; IDA:HGNC-UCL.
DR GO; GO:0042581; C:specific granule; ISO:RGD.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0042589; C:zymogen granule membrane; ISO:RGD.
DR GO; GO:0050544; F:arachidonic acid binding; IDA:HGNC-UCL.
DR GO; GO:0005484; F:SNAP receptor activity; IDA:FlyBase.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0098967; P:exocytic insertion of neurotransmitter receptor to postsynaptic membrane; ISO:RGD.
DR GO; GO:0006887; P:exocytosis; ISO:RGD.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0046907; P:intracellular transport; TAS:RGD.
DR GO; GO:0060291; P:long-term synaptic potentiation; ISO:RGD.
DR GO; GO:0061025; P:membrane fusion; IDA:RGD.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; ISO:RGD.
DR GO; GO:0031175; P:neuron projection development; IDA:HGNC-UCL.
DR GO; GO:0090174; P:organelle membrane fusion; ISS:UniProtKB.
DR GO; GO:0045785; P:positive regulation of cell adhesion; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0050921; P:positive regulation of chemotaxis; ISO:RGD.
DR GO; GO:2000010; P:positive regulation of protein localization to cell surface; ISO:RGD.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISO:RGD.
DR GO; GO:0010468; P:regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0016081; P:synaptic vesicle docking; TAS:RGD.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; TAS:RGD.
DR GO; GO:0099003; P:vesicle-mediated transport in synapse; ISO:RGD.
DR CDD; cd15881; SNARE_syntaxin3; 1.
DR CDD; cd00179; SynN; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 1.20.58.70; -; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR031186; STX3_SNARE.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; SYNTAXIN; 1.
DR PANTHER; PTHR19957:SF34; SYNTAXIN-3; 1.
DR Pfam; PF05739; SNARE; 1.
DR Pfam; PF00804; Syntaxin; 1.
DR SMART; SM00503; SynN; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; t-snare proteins; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Neurotransmitter transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..289
FT /note="Syntaxin-3"
FT /id="PRO_0000210201"
FT TOPO_DOM 1..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 191..253
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT COILED 32..111
FT /evidence="ECO:0000255"
SQ SEQUENCE 289 AA; 33257 MW; 4A8EAFD4684EEE6F CRC64;
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS EHVEEAKKLY
SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH
SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ RQLEITGKKT TDEELEEMLE SGNPAIFTSG
IIDSQISKQA LSEIEGRHKD IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV
DHVEKARDET KRAMKYQGQA RKKLIIIIVI VVVLLGILAL IIGLSVGLK
//
