ID SWAHC_HUMAN Reviewed; 525 AA.
AC Q53LP3; Q8NE15; Q9H6U1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 141.
DE RecName: Full=Ankyrin repeat domain-containing protein SOWAHC;
DE AltName: Full=Ankyrin repeat domain-containing protein 57;
DE AltName: Full=Protein sosondowah homolog C;
GN Name=SOWAHC; Synonyms=ANKRD57, C2orf26;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein phosphorylation
RT analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SIMILARITY: Belongs to the SOWAH family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15161.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK025523; BAB15161.1; ALT_FRAME; mRNA.
DR EMBL; AC140485; AAY24143.1; -; Genomic_DNA.
DR EMBL; AC011753; AAY24292.1; -; Genomic_DNA.
DR EMBL; BC036652; AAH36652.2; -; mRNA.
DR CCDS; CCDS33270.1; -.
DR RefSeq; NP_075392.2; NM_023016.3.
DR AlphaFoldDB; Q53LP3; -.
DR SMR; Q53LP3; -.
DR BioGRID; 122402; 26.
DR IntAct; Q53LP3; 4.
DR STRING; 9606.ENSP00000365830; -.
DR iPTMnet; Q53LP3; -.
DR PhosphoSitePlus; Q53LP3; -.
DR BioMuta; SOWAHC; -.
DR DMDM; 74740628; -.
DR EPD; Q53LP3; -.
DR jPOST; Q53LP3; -.
DR MassIVE; Q53LP3; -.
DR MaxQB; Q53LP3; -.
DR PaxDb; 9606-ENSP00000365830; -.
DR PeptideAtlas; Q53LP3; -.
DR ProteomicsDB; 62510; -.
DR Pumba; Q53LP3; -.
DR Antibodypedia; 33168; 112 antibodies from 19 providers.
DR DNASU; 65124; -.
DR Ensembl; ENST00000356454.5; ENSP00000365830.2; ENSG00000198142.5.
DR GeneID; 65124; -.
DR KEGG; hsa:65124; -.
DR MANE-Select; ENST00000356454.5; ENSP00000365830.2; NM_023016.4; NP_075392.2.
DR UCSC; uc002tfb.4; human.
DR AGR; HGNC:26149; -.
DR CTD; 65124; -.
DR GeneCards; SOWAHC; -.
DR HGNC; HGNC:26149; SOWAHC.
DR HPA; ENSG00000198142; Low tissue specificity.
DR neXtProt; NX_Q53LP3; -.
DR OpenTargets; ENSG00000198142; -.
DR PharmGKB; PA134882354; -.
DR VEuPathDB; HostDB:ENSG00000198142; -.
DR eggNOG; ENOG502QVDE; Eukaryota.
DR GeneTree; ENSGT00950000183003; -.
DR HOGENOM; CLU_041239_2_0_1; -.
DR InParanoid; Q53LP3; -.
DR OMA; PHGCEEA; -.
DR OrthoDB; 46661at2759; -.
DR PhylomeDB; Q53LP3; -.
DR TreeFam; TF331362; -.
DR PathwayCommons; Q53LP3; -.
DR Reactome; R-HSA-8980692; RHOA GTPase cycle.
DR Reactome; R-HSA-9013026; RHOB GTPase cycle.
DR Reactome; R-HSA-9035034; RHOF GTPase cycle.
DR SignaLink; Q53LP3; -.
DR BioGRID-ORCS; 65124; 18 hits in 1144 CRISPR screens.
DR GenomeRNAi; 65124; -.
DR Pharos; Q53LP3; Tdark.
DR PRO; PR:Q53LP3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q53LP3; Protein.
DR Bgee; ENSG00000198142; Expressed in esophagus squamous epithelium and 184 other cell types or tissues.
DR Genevisible; Q53LP3; HS.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR14491:SF4; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHC; 1.
DR PANTHER; PTHR14491; UNCHARACTERIZED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..525
FT /note="Ankyrin repeat domain-containing protein SOWAHC"
FT /id="PRO_0000274340"
FT REPEAT 301..330
FT /note="ANK 1"
FT REPEAT 340..370
FT /note="ANK 2"
FT REGION 84..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 88
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C0J6"
FT MOD_RES 126
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 213
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 226
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:16964243"
FT CONFLICT 307
FT /note="H -> R (in Ref. 1; BAB15161)"
FT /evidence="ECO:0000305"
FT CONFLICT 318
FT /note="L -> V (in Ref. 1; BAB15161)"
FT /evidence="ECO:0000305"
FT CONFLICT 334
FT /note="I -> M (in Ref. 1; BAB15161)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 525 AA; 55672 MW; 6E90B5E911D41B02 CRC64;
MEGPAEWGPE AALGPEAVLR FLAERGGRAL HAELVQHFRG ALGGEPEQRA RARAHFKELV
NAVATVRVDP ADGAKYVHLK KRFCEGPSEP SGDPPRIQVT AEPEAPDGPA GPEARDRLPD
AAAPESLPGQ GRELGEGEPP APAHWPPLSA GARRKNSRRD VQPLPRTPAP GPSEDLELPP
HGCEEADRGS SLVGATAQRP ARQNLRDLVM GSSPQLKRSV CPGGSSPGSS SGGGRGRGGG
DSDSASVASS SAEEESSGGG SVTLDPLEHA WMLSASDGKW DSLEGLLTCE PGLLVKRDFI
TGFTCLHWAA KHGRQELLAM LVNFANKHQL PVNIDARTSG GYTALHLAAM HGHVEVVKLL
VGAYDADVDI RDYSGKKASQ YLSRSIAEEI KNLVGALDEG DGESAAGSGG GRWRLSKVLP
SHLITYKLSH ALEDGGDHHH HHHSAEGWVG GKAKDPGRKA SGSSSGRIKP RLNKIRFRTQ
IVHTTPSFRD PEQPLEGRGE EGVGEERPVK GHSPFTLRPK SNVFG
//
