ID   T0H4W4_9LEPT            Unreviewed;       632 AA.
AC   T0H4W4;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Polysaccharide biosynthesis protein {ECO:0000313|EMBL:EQA78823.1};
GN   ORFNames=LEP1GSC193_1719 {ECO:0000313|EMBL:EQA78823.1};
OS   Leptospira alstonii serovar Pingchang str. 80-412.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1218564 {ECO:0000313|EMBL:EQA78823.1, ECO:0000313|Proteomes:UP000015445};
RN   [1] {ECO:0000313|EMBL:EQA78823.1, ECO:0000313|Proteomes:UP000015445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=80-412 {ECO:0000313|EMBL:EQA78823.1,
RC   ECO:0000313|Proteomes:UP000015445};
RA   Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA   Sanka R., DePew J., Purushe J., Galloway R.L., Vinetz J.M., Sutton G.G.,
RA   Nierman W.C., Fouts D.E.;
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000256|ARBA:ARBA00007430}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQA78823.1}.
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DR   EMBL; AOHD02000062; EQA78823.1; -; Genomic_DNA.
DR   RefSeq; WP_020772455.1; NZ_AOHD02000062.1.
DR   AlphaFoldDB; T0H4W4; -.
DR   STRING; 28452.A0128_21155; -.
DR   Proteomes; UP000015445; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF13727; CoA_binding_3; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        43..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          285..569
FT                   /note="Polysaccharide biosynthesis protein CapD-like"
FT                   /evidence="ECO:0000259|Pfam:PF02719"
SQ   SEQUENCE   632 AA;  71144 MW;  37A249602A6D964A CRC64;
     MLGQWNRRMW IFPLDLLFMG ASYFLAHWIR FESFVFLASP ERFFTSLIIV ITVRAGVFIL
     SDIYRSIWVY ASIHDLVEII KVTLLSSLIS TTALLFYNRF EQLSRMVPVL DTLLLLSFLC
     IRSFSWRVFR DQYILKKSKE EGLPTLILGA GKVGATLLSE IRRHNELKLN PIGFLDDNVQ
     KIGAHIQGIP ILAKIDQAEQ MINRFGVKQV IIAITNPDGK LISRLIRSFE NTDVKFKILP
     SLGSLFFDSP KLNQLREVQV EDLLGRPVVD LEIESIRSYL KGKSILVTGA GGSIGSELCR
     QVAVFEPSRI LLLDSAETPL YEIEYELGKK LQGQNIELIP IVADIKNISR ISSIFERHSP
     QVVFHSAAYK HVPMMEVNPT EAVMNNVLGT KNIADISRIS GVERFVLIST DKAVNPVNIM
     GASKRAAELY LQHISRETRT KFITVRFGNV LGSNGSVIPR FREQIANGGP VTVTHPDVIR
     YFMTIPEATQ LVLQAGSMGE CGEIFILEMG EPVKILNLAE EMIRLCGLRP HVDIPIQFTG
     LRPGEKLFEE LLLDLEGIKK THHPKIKIAA PLENQEVTTF VARFNELLTA GRTNKDKDIF
     FAFKALVPEY KIHGDYLNEA NAGISDQNLK NG
//