ID T0L8I2_9MICR Unreviewed; 1001 AA.
AC T0L8I2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Dead deah box helicase {ECO:0000313|EMBL:EQB60823.1};
GN ORFNames=NAPIS_ORF01608 {ECO:0000313|EMBL:EQB60823.1};
OS Vairimorpha apis BRL 01.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae;
OC Vairimorpha.
OX NCBI_TaxID=1037528 {ECO:0000313|EMBL:EQB60823.1, ECO:0000313|Proteomes:UP000053780};
RN [1] {ECO:0000313|EMBL:EQB60823.1, ECO:0000313|Proteomes:UP000053780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRL 01 {ECO:0000313|EMBL:EQB60823.1,
RC ECO:0000313|Proteomes:UP000053780};
RX PubMed=23829473; DOI=10.1186/1471-2164-14-451;
RA Chen Yp., Pettis J.S., Zhao Y., Liu X., Tallon L.J., Sadzewicz L.D., Li R.,
RA Zheng H., Huang S., Zhang X., Hamilton M.C., Pernal S.F.,
RA Melathopoulos A.P., Yan X., Evans J.D.;
RT "Genome sequencing and comparative genomics of honey bee microsporidia,
RT Nosema apis reveal novel insights into host-parasite interactions.";
RL BMC Genomics 14:451-451(2013).
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DR EMBL; KE647232; EQB60823.1; -; Genomic_DNA.
DR AlphaFoldDB; T0L8I2; -.
DR VEuPathDB; MicrosporidiaDB:NAPIS_ORF01608; -.
DR HOGENOM; CLU_004167_0_0_1; -.
DR Proteomes; UP000053780; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF6; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EQB60823.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053780}.
FT DOMAIN 115..285
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 306..508
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1001 AA; 117842 MW; 33FC264D0B0DD892 CRC64;
MDEALYKCAK KLKLTPTELK KIIIQLLSKE TYQEELFELL GFENIDFIEA VCKNKDYFSI
KTEDKKTKEF FTEFILPEFE TIKYEKELVS TKILDYNKIY FEYDVFNPVQ SEVFYTAYKT
NENFLVCAPT GTGKTDIALL CILKAIKMYK AMIIYIVPMK ALASEITSKF KKKLKDFIVL
EFTGDTELKT KDIINANVIV CTPEKFDVYT RKMSNVFLEK VNLVIIDEIH ILQEDRGCVI
EAIVSRLFRY IELNQKYIRI IGLSATLPNY KDVSKFLKAT KTYNFEQNYR PVPLKTSILG
VFENINKKQK LQILRDRVDN FRFNKKQILV FVNSRNETLY IAKYLIDKEI EQNFKNKINL
NSKLELIVKH KIGIHHAGLP RNIRLFMENK FKNGELDILV CTSTLAWGVN LPAHVVIING
TQFYDPNIGR FRDLGILDIF QIFGRAGRPQ YKITGEAILI TEYNKVGNYL KMLKNNTPIE
SKLLNKIANL VNSEIYLECI KSVSDGLQWL KNTFMYIRMK LNPTLYGLKE EDINNEDVVL
ADYIFLTIKR LEECNLIKIN KCLNDDFMTW KFESTEFGRI SSFYYLEHCT IQEWLRKVDY
LSSIDDIINL ILENKDFENI QSRKEEEYQL LELASAIGIL SLDVLEYKKY ILEIAYLKHY
PITHFSLKCD SMFIAKNFER ILGAFIDFLR YLKKFNLLYI SLKILNKILI SNLNKSLNKE
KNSKYEISIL DCDEFIRIKI LAINKFWIIL SCSGEIFYIN SCKGNFDGFI KKPIINVKTI
TVEIFDIDNN KFFKNEENII ECNNQQNILN EGFHSCTKKI SIIEEYTECD HIKIYRKDCI
KPIYYSSKLE LYGSYFINIS FFVTHYNVYN EFRKKFVEIS MSNFLSKDSL LIICKSMTDV
NILKVEIYTK IALYNLETNK NVFKHITNDL DEQNSNTIFL TTFEKAKSFK SKIFTIFLTC
KNEQNLFYPI FDILELCNNR KVLIFENVEF IDYFRCSILK N
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