ID T0LUU1_COLGC Unreviewed; 1513 AA.
AC T0LUU1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
DE AltName: Full=Vacuolar carboxypeptidase Sorting receptor VPS10 {ECO:0000256|ARBA:ARBA00032705, ECO:0000256|ARBA:ARBA00032910};
GN ORFNames=CGLO_08336 {ECO:0000313|EMBL:EQB52065.1};
OS Colletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus)
OS (Glomerella cingulata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum gloeosporioides species complex.
OX NCBI_TaxID=1237896 {ECO:0000313|EMBL:EQB52065.1, ECO:0000313|Proteomes:UP000015530};
RN [1] {ECO:0000313|Proteomes:UP000015530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cg-14 {ECO:0000313|Proteomes:UP000015530};
RX PubMed=23902260; DOI=10.1094/MPMI-03-13-0080-R;
RA Alkan N., Meng X., Friedlander G., Reuveni E., Sukno S., Sherman A.,
RA Thon M., Fluhr R., Prusky D.;
RT "Global aspects of pacC regulation of pathogenicity genes in Colletotrichum
RT gloeosporioides as revealed by transcriptome analysis.";
RL Mol. Plant Microbe Interact. 26:1345-1358(2013).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB52065.1}.
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DR EMBL; AMYD01001676; EQB52065.1; -; Genomic_DNA.
DR STRING; 1237896.T0LUU1; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000015530; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 2.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000015530};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1513
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004580335"
FT TRANSMEM 1382..1403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1430..1453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..685
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 737..1371
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1513 AA; 170031 MW; 60AC9311D93D75A5 CRC64;
MRLGGKAAAS WRILLSVLTW TAAVHAKDDP TISVTTTKHP PAGLSYFEDS DVILYHDISE
RNIYRTDDAG VTWNKVKGIP DDKAALFVMH EFDKSRAYVL TETNKHYRTT DKGKTWDEFD
SVIEKSFFQG ADILHFHAGD PDRIIFGGMQ CAGIFCQEVA MYTTDNFKSK AKPLRNNIVG
CWWAKSSTMF TTGQKDLDEQ RILCIALDKS STSKYDYRLF ASDNYFEEKG NQIQEFEPNM
DTNKGVSGVV NLAVVKKYLM VATSSPNTDE MALFVTDDTI KWHRAMFPAA HGHKINQDAY
TVLESTNYSI QVDVVNTGTS NPMGVMFTSN SNGTFFIENI EHTNRNRRGH VDFEKITGVQ
GVFIVNVVKN AEEVEKNHKA AKEIITKITF DDGRNFHELK AGSDNIHLHS VTDLDNVGRV
FSSPAPGLVL GIGNTGKSLG KFEEGDVFVS DDAGVTWKKA LDGPHKYEFG DQGSILVAVK
DSYKEDVSEV RYSLDHGESW KKVALPKDLK IKPELLTTTQ DSTSLKFLLV GRTGGGDNPN
FHLIALDFEG LHERTCKDDD MEDWHARPDD NGKPTCLMGH KQTYRRRKKT ADCFIEQEFK
DPVPVTEDCE CTDADFECDY NFVRKDGKCE IAGPIIKPDG ACKNAKAEDT FKGTSGWRLI
PGNTCKRKSG AQKDDPVERK CGDTDTRPSV PVDGKVKAIK HTFDTKKTDF EKFYLERGET
NKETDETIIV RPIEYTSSGQ MKIDPSAPIW RTKNHGKDWD TILKDEKIYG IYPHNHFKDT
VFFTTDSKKV MYTIDHAEHF HHFDAPTEAD TEMGSPLSFH PDKKDWLIWV GKKCEKDECW
HEASITKDRG DNWHTALRYV RKCEFTGNSA YKFRDARQIV CLANKEENND KGTPRVVVSS
NDFFEEDKQY HQSDVSDFAT MAEFIVVAVE DKQKDDLKPY ASLDGVTYAE AHFPVNFKVG
HKNAYTVLDS STHAVNLFVA TSSAEGRRYG SIIKSNSNGT SYVQSAAKVN CDDSYYVDFE
KIAGLEGVAL INTVINSDKE SEPKKVHTQI SHNDGAQWAF LPPPRKDAAD KNYECSSNEG
DEKCALHLHH YTERTDKKKT FSAATAIGVM FGNGNVGSSL GSIKDADTFM STDAGITWKS
VAKGVWTWQY GDQGSIIVLV QRYTTATPNK SNVFKYSTNG GKDWEEQKFD ENEVKIMDIT
TVRSGSSRNF LLWCKSDKDE MFTVDIDFTG LTDKPCKYEK NGESDYYTWS PKHPMQADNC
LFGHVTEYLR KREDRNCFND GRVERLPQIS NCTCTRPDFE CDYNFELDNH KQCSLVPGKQ
PLSAEQWCKE NPDAVEYYEP TGYRRIPLTT CVGGQELDKQ SQVHACAGKE DEFERRRGTS
GVAIFFAVII PVGVAAAIGW WVYNNWNSKF GQIRLGESPS MDSEAPWVKY PVIALSAVVA
VVSALPLVAS AVWRSATSAY ERVSSGSRGG SWLSGRGNRR FTTRDSFARG RGDYAVVDDD
EGELLGDESD DEV
//
