ID T0MKQ0_CAMFR Unreviewed; 584 AA.
AC T0MKQ0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Complement component C7 {ECO:0000313|EMBL:EQB79060.1};
GN ORFNames=CB1_001954004 {ECO:0000313|EMBL:EQB79060.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EQB79060.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EQB79060.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB018023; EQB79060.1; -; Genomic_DNA.
DR AlphaFoldDB; T0MKQ0; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 1.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR048827; C7_FIM2_N.
DR InterPro; IPR048825; C7_KAZAL.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR040729; Kazal_3.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF2; COMPLEMENT COMPONENT C7; 1.
DR Pfam; PF21284; C7_FIM2_N; 1.
DR Pfam; PF21330; C7_KAZAL; 1.
DR Pfam; PF18434; Kazal_3; 1.
DR Pfam; PF01823; MACPF; 2.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00032; CCP; 1.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT DOMAIN 370..431
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..82
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 64550 MW; 9D3DFD70E829DFC7 CRC64;
MSYSTIFLSS NPIPSPASPN QGKEDYLESV GYSEDAETTV EEEDSDDPEC IIYDGKEDSV
YSETTEFSDE EQNDEDSEAG VSLEEEEEKR LEGQCISKSL VCNGDSDCEE DSADEDRCED
SESRPSCDLY QPPPNIELTG NGHNSDTNEI HKTKSYQLLV VQNTVEVAQF INSNPEFLQL
AEPFWKELSY LPSLYDYSAY RRLIDKYGTH YLQSGSLGGE YKIIFHVDSE KSKELVETQG
NVLRGNPFVL GGRSGLVSGL SYLELDNPAG NKQRYSSWAG SVTDLPQVIK QKLTPLYELV
KEVPCASVKR LYLKRAMEEY LDEFDPCHCR PCQNGGIATV EGTQCQCHCK PYTFGVACER
GALVGNHAEI ACVLPALMDG MQSHPHKAFY TVGEKVAISC SGGMSVEGPS TFLCGSSLKW
SPEMKNVQCV QKDAPLVQKV PECQRWEKLQ NSRCVCKMPY ECGSSLDVCA RDERSKRILP
LTVCKMHVLQ CQGRNYTVTG RESCTLPASV EKACGVCPLW GKCDAQSSKC VCRAASECEE
EGFSVCVDVN GKERTMTECE AGVLRCRGQS ISVTSIRPCA TEAP
//
