ID T0NP70_CAMFR Unreviewed; 1173 AA.
AC T0NP70;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=CB1_000277008 {ECO:0000313|EMBL:EQB77322.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EQB77322.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EQB77322.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
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DR EMBL; KB016570; EQB77322.1; -; Genomic_DNA.
DR AlphaFoldDB; T0NP70; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06659; STKc_PAK6; 1.
DR Gene3D; 1.25.40.430; -; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR035066; STKc_PAK6.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF19; SERINE_THREONINE-PROTEIN KINASE PAK 6; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:EQB77322.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Transferase {ECO:0000313|EMBL:EQB77322.1}.
FT DOMAIN 576..589
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 899..1150
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 183..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 333..367
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 762..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 928
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1173 AA; 131536 MW; ACF96D08802101D5 CRC64;
MQKERGAPSE VMSLEGDEWE LSKENVQPLR QGRIMSSLQG ALAQQESACN TALQQQKRCV
EWLGLNLSSF IPNCGRAFES EIRFYAGNDP LDVWDRQFQA RVSRQTLLAL EKDEEEEVFV
SSVPQRSTLA ELKSKGKKTA RAPISRVGGA LKALSQNRGL QNPVPQQMQS NSRITVFDEN
ADEASRAESK PTVQPWTAPP VPRAKENELQ AGPWNTSRPL EYRPRGSTAS MTAVPSVLPS
FTPYVEETAQ QPVMTPCKIE PSINHVLSTR KPGKEEGDLL QRVQSHQQES EEKKEKMMYC
KEKIYAGVGE FSFEEIRAEV FRKKLKERRE AELLTSAEKR AEMQKQIEEM EKKLKEIQTT
QQERAEDTCD FARAARFAST PFHEVISLKD LPSDPERLLQ EEDLDVKTSE DQQTASGIIY
NPTLSIKKLR IHDPYDCNKN NEALKIVDFS YSVDLRAQLD VFNLSGFRTV QILEGQKILA
NCSSPYQLEQ MLFLSSLYLE KLAEVNESIP LLPPETVKPR KEVWAEITSR TRESCAPGPR
PRAPWAWQKL GCWVEDGDLE MASTMFRKKK KKRPEISAPQ NFQHRVHTSF DPKEGKFVGL
PPQWQNILDT LRRPKPVVDP SRITRVQLQP MKTVVRGSAA PMDGYISGLL NDIQKLSVIS
SNTLRGRSPT SRRRAQSLGL LGDEQWAADP DMYLQSPKSE RTDPHGLYLS CNGGAPAGHR
QVPWPEPQSP RVLPNGLATK AQSLGPTEFQ GATQRCLQLG TCLQRSPPGT SPPTATGRRG
TKTARHGSEE ARPQSCLGGW ATGRPGGEGS PSPKTQENSL KRRLFRSMFL SASATASPSS
SKPGPQPQSK ISTSNLYLPQ DPAVAKGALA SEDTGVVTHE QFKAALRMVV DQGDPRLLLD
SYVKIGEGST GIVCLAREKH SGRQVAVKMM DLRKQQRREL LFNEVVIMRD YQHLNVVEMY
KSYLVGEELW VLMEFLQGGA LTDIISQVRL NEEQIATVCE AVLQALAYLH TQGVIHRDIK
SDSILLTLDG RVKLSDFGFC AQISKDVPKR KSLVGTPYWM APEVISRSLY ATEVDIWSLG
IMVIEMVDGE PPYFSDSPVQ AMKRLRDSPP PRLKNSHKVS PVLRDFLERM LVRDPQERAT
AQELLDHPFL LQTGLPECLV PLIQLYRKQT STC
//
