ID T0UV86_LACLC Unreviewed; 419 AA.
AC T0UV86;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Diaminopimelate decarboxylase {ECO:0000313|EMBL:EQC87612.1};
GN ORFNames=LLT1_09675 {ECO:0000313|EMBL:EQC87612.1};
OS Lactococcus cremoris subsp. cremoris TIFN1.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus; Lactococcus cremoris subsp. cremoris.
OX NCBI_TaxID=1234871 {ECO:0000313|EMBL:EQC87612.1, ECO:0000313|Proteomes:UP000015849};
RN [1] {ECO:0000313|EMBL:EQC87612.1, ECO:0000313|Proteomes:UP000015849}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TIFN1 {ECO:0000313|EMBL:EQC87612.1};
RX PubMed=23823494; DOI=10.1038/ismej.2013.108;
RA Erkus O., de Jager V.C., Spus M., van Alen-Boerrigter I.J.,
RA van Rijswijck I.M., Hazelwood L., Janssen P.W., van Hijum S.A.,
RA Kleerebezem M., Smid E.J.;
RT "Multifactorial diversity sustains microbial community stability.";
RL ISME J. 7:2126-2136(2013).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR600183-50};
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
CC {ECO:0000256|RuleBase:RU003737}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQC87612.1}.
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DR EMBL; ASXF01000111; EQC87612.1; -; Genomic_DNA.
DR AlphaFoldDB; T0UV86; -.
DR PATRIC; fig|1234871.3.peg.947; -.
DR Proteomes; UP000015849; Unassembled WGS sequence.
DR GO; GO:0008836; F:diaminopimelate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro.
DR CDD; cd06828; PLPDE_III_DapDC; 1.
DR Gene3D; 3.20.20.10; Alanine racemase; 1.
DR InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR InterPro; IPR002986; DAP_deCOOHase_LysA.
DR InterPro; IPR022643; De-COase2_C.
DR InterPro; IPR022644; De-COase2_N.
DR InterPro; IPR000183; Orn/DAP/Arg_de-COase.
DR InterPro; IPR029066; PLP-binding_barrel.
DR PANTHER; PTHR43727; DIAMINOPIMELATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43727:SF2; DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF02784; Orn_Arg_deC_N; 1.
DR Pfam; PF00278; Orn_DAP_Arg_deC; 1.
DR PRINTS; PR01181; DAPDCRBXLASE.
DR PRINTS; PR01179; ODADCRBXLASE.
DR SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1.
DR SUPFAM; SSF51419; PLP-binding barrel; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR600183-50}.
FT DOMAIN 30..279
FT /note="Orn/DAP/Arg decarboxylase 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02784"
FT DOMAIN 281..369
FT /note="Orn/DAP/Arg decarboxylase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00278"
FT ACT_SITE 342
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
FT MOD_RES 54
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
SQ SEQUENCE 419 AA; 47247 MW; BBC1CDA1C2FBB530 CRC64;
MKTPFVTKEQ LEQITAEYPT PFHLYDEKGI RQKARDLHKA FAWNKGFKEF FAVKATPTPA
ILKILHEEGC GVDCASYIEL LLSEKCGFDG TEMMFSSNDT PAEEFQFANQ LGATINLDAY
EHIEFLKNLP DFVFPKTMSL RYNPGGVFAM GTKIMDNPEE SKFGMTKAQL IQGIKDLQKL
GVKEFGMHSF LASNTVTNDY YPELARKLFE LELEIRQETG VTLDFINLSG GIGVNYRPDE
EANDIAKIGQ GVHKAYEEVL TANGIENLKI YTELGRFMLA PHGHLITKVL HLKETYRKYV
GVDASAVNLM RPAFYDAYHH ITVAGKEKQE ATETYDITGS LCENNDKFAK ERAFPEIKVG
DLLVIHDTGA HGFSMGYQYN AKLRSAEILL QEDGKTRLIC RAENPADYFA TLDGFDFNN
//
