ID   T1DQN9_ANOAQ            Unreviewed;       783 AA.
AC   T1DQN9;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Protein SDA1 {ECO:0000256|RuleBase:RU365057};
OS   Anopheles aquasalis (Malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=42839 {ECO:0000313|EMBL:JAA99236.1};
RN   [1] {ECO:0000313|EMBL:JAA99236.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Whole body {ECO:0000313|EMBL:JAA99236.1};
RG   Brazilian Malaria Network (MCT/CNPq/MS/SCTIE/DECIT/PRONEX 555648/2009-5) and Research Network on Bioactive Molecules from Arthropod Vectors (NAP-MOBIARVE;
RG   University of Sao Paulo);
RA   Marinotti O., Ribeiro J.M.C., Costa-da-Silva A.L., Silva M.C.P.,
RA   Lopes A.R., Barros M.S., Sa-Nunes A., Konjin B.B., Carvalho E., Suesdek L.,
RA   Silva-Neto M.A.C., Capurro M.L.;
RT   "Transcriptome sequencing and developmental regulation of gene expression
RT   in Anopheles aquasalis.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC       cytoplasm. {ECO:0000256|RuleBase:RU365057}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|RuleBase:RU365057}.
CC   -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000256|ARBA:ARBA00005783,
CC       ECO:0000256|RuleBase:RU365057}.
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DR   EMBL; GAMD01002354; JAA99236.1; -; mRNA.
DR   AlphaFoldDB; T1DQN9; -.
DR   VEuPathDB; VectorBase:AAQUA_012078; -.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:UniProtKB-UniRule.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR027312; Sda1.
DR   InterPro; IPR048292; SDA1_C.
DR   InterPro; IPR007949; SDA1_MD.
DR   InterPro; IPR012977; SDA1_N.
DR   PANTHER; PTHR12730; HSDA/SDA1-RELATED; 1.
DR   PANTHER; PTHR12730:SF0; PROTEIN SDA1 HOMOLOG; 1.
DR   Pfam; PF21638; SDA1_C; 1.
DR   Pfam; PF05285; SDA1_dom; 1.
DR   Pfam; PF08158; SDA1_HEAT; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   2: Evidence at transcript level;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365057};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU365057};
KW   Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW   ECO:0000256|RuleBase:RU365057};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365057}.
FT   DOMAIN          60..422
FT                   /note="SDA1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08158"
FT   DOMAIN          505..719
FT                   /note="SDA1 middle"
FT                   /evidence="ECO:0000259|Pfam:PF05285"
FT   DOMAIN          737..782
FT                   /note="SDA1 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21638"
FT   REGION          479..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..498
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        547..587
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        588..603
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        604..620
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   783 AA;  90833 MW;  42BBB29E574A389D CRC64;
     MRHNNQLPDN LPQLQNLIKR DPESYREEFL QQHQHFLSVL DIFRLEPDKE NKSLCESIMF
     LAQIAQCYLE DLKTFPQTLV DLLKTHSTTL DPEMRNTFCR ALILLRNKNL ISPLDLLELF
     FQLLRCPDKA LRTFLENHII TDIKNMNAKQ KDMKLNSTLQ SFMYTMLRDS NPKAAKMSVD
     IMIELYRKQV WNDAKTVNVI ANVGCFSKVT KVMVASLKFF LGTDQQNESD DDDSDREVDL
     KGVMMATRVN KKTKKRKKQL EAAKKLYTQA QKKKSKPVAF NFSAIHLIHN PQGMAENLFK
     QLQDGNERFE VKLMHLDVIS RLIGIHELFL FSFYPYITRF IQPHQRQVTR ILQFAAQASH
     ELVPPEIIEP VIKTLVNNFV TERNSSDVMA IGLNAVREIC LRCPLAMTED LLRDLVMYKN
     YKEKSVMMAS KSLIMLYREQ IPTLLAKKDR GRPTEASVEI KPKRYGEVLA NEYIPGTEAL
     LREDAPELDE DDESASGSGS DDSDWVDVDS SEDECDALLR EEKSKSMKGI TMIKSAKSKQ
     QEQSESEESD QTEDDEDEED TDDEEDDEDE GEWEECSEEE ELEEDDETEV VPKGKAKEKQ
     KPLVISKRKG KKNKKKKTII TVSGAKKDDA EPETTTVGES DQTLNTAEAM QELALTKIFT
     DADFARIEQE RVKKQVTHHS RKRQLETERN EFVKLDSIEM IYKRRKTDKE ARVESMKKGR
     EGREKFGYKD NRLNPHCSKT NREKRKTKNF GMIRHKARGK VKKSFRDKQL ALRKHLMNMK
     KMK
//