ID   T1E4I7_CROHD            Unreviewed;       266 AA.
AC   T1E4I7;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Replication factor A protein 2 {ECO:0000256|ARBA:ARBA00043137};
OS   Crotalus horridus (Timber rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=35024 {ECO:0000313|EMBL:JAA95918.1};
RN   [1] {ECO:0000313|EMBL:JAA95918.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Venom gland {ECO:0000313|EMBL:JAA95918.1};
RX   PubMed=23758969; DOI=10.1186/1471-2164-14-394;
RA   Rokyta D.R., Wray K.P., Margres M.J.;
RT   "The genesis of an exceptionally lethal venom in the timber rattlesnake
RT   (Crotalus horridus) revealed through comparative venom-gland
RT   transcriptomics.";
RL   BMC Genomics 14:394-394(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the replication factor A protein 2 family.
CC       {ECO:0000256|ARBA:ARBA00007815}.
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DR   EMBL; GAAZ01002025; JAA95918.1; -; mRNA.
DR   AlphaFoldDB; T1E4I7; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd04478; RPA2_DBD_D; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR040260; RFA2-like.
DR   InterPro; IPR014646; Rfa2/RPA32.
DR   InterPro; IPR014892; RPA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13989:SF16; REPLICATION PROTEIN A 32 KDA SUBUNIT; 1.
DR   PANTHER; PTHR13989; REPLICATION PROTEIN A-RELATED; 1.
DR   Pfam; PF08784; RPA_C; 1.
DR   PIRSF; PIRSF036949; RPA32; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          161..258
FT                   /note="Replication protein A C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08784"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   266 AA;  29446 MW;  3F206C5013D8168B CRC64;
     MWSGHGGYDS NYGNYTQSPG GFTSPSATQG ERKSRSRSQN IVPCTVSQLF SAEQVDDVFR
     VREVELSQVI IVGIIRHAEK APTNILYKVD DMTAAPMDVR QWVDTDEEGS ENVVVPPGTY
     VKVAGHLRSF QNKKSLVAFK IMPLEDMNEF TTHLLEVVNA HMVLRKSNTP QSSKIPQSFG
     VFETSSMSNA GGNDSLTMHG LTPHQSQVLN LIKSCMTTEG ISLHDLKSQL HNINLQTLKK
     AVEFLSSEGH IYSTIDDEHF KSTDAD
//