ID T1EDT4_HELRO Unreviewed; 641 AA.
AC T1EDT4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=20194736 {ECO:0000313|EnsemblMetazoa:HelroP105295};
GN ORFNames=HELRODRAFT_105295 {ECO:0000313|EMBL:ESO12355.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP105295, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO12355.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP105295}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; AMQM01000147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO12355.1; -; Genomic_DNA.
DR RefSeq; XP_009009075.1; XM_009010827.1.
DR AlphaFoldDB; T1EDT4; -.
DR EnsemblMetazoa; HelroT105295; HelroP105295; HelroG105295.
DR GeneID; 20194736; -.
DR KEGG; hro:HELRODRAFT_105295; -.
DR CTD; 20194736; -.
DR eggNOG; KOG4418; Eukaryota.
DR HOGENOM; CLU_018068_2_1_1; -.
DR InParanoid; T1EDT4; -.
DR OMA; WHGYRTR; -.
DR OrthoDB; 3430189at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF26; SMOG, ISOFORM D; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 239..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 227..455
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 525..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..562
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 73754 MW; C0EF804508F90BB9 CRC64;
MRQIFEKLKL KHEPQSKNFK AICNESRNVF DSMRSSNEMK MWGDLSYDCL TKRWRVLRIE
PLYQCVNSSL PPLSGMIKFD IHLDELALDP CSVSKPNSIF QHKCPAHSQC ISSQLKTKWK
RTSSYACKCL KGYYNKYFMQ INLSKESTEL NSSNCISGHL MDQTYVDKLL NRSIRWDFEC
VPCAAGCEEC VNDRACNLSF DVLNRGVPLA VESISLTICT ALFCSIFKLR KTKVMKGSIW
FLLETVVFGA FLLYTTVIIR YFEPNNCLCI VVQWFREVGF ACVYGSLILK VYRVLTEFQS
RKAHRVQMRN KDLIKCLICI VVVVVGYMAA WTAVNIDSMD GHDWSMLWTV YKDGLKFELC
RTVSWDFVII LAEILFLSFG IRLCYRARSA PSSHKEIFCI TFALCNEIVI SGLFYTLRHF
LVKQLHPDHL FLMYFLRCQL TVSTLLAAVV GPKLWFAHQP LDDMTLRNRA YSSSEHEHSS
PEVVKLNIKP NGDLDNGEFL LTEFNPEDIR YELKRLYTQL QIYKTKTMRQ DNPHIPKRRG
GRKQTHRRFS LQAFHNKHKR PHSDHGNVSS SGGGGETEVS RTPEESTNSA EGVSVYMDEC
SALESNNNNN FNNNVNIATN SASRIFTGIV KSKRKNSELN K
//
