ID T1F2D6_HELRO Unreviewed; 410 AA.
AC T1F2D6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Outer dynein arm-docking complex subunit 4 {ECO:0000256|ARBA:ARBA00034139};
DE AltName: Full=Tetratricopeptide repeat protein 25 {ECO:0000256|ARBA:ARBA00034143};
GN Name=20202986 {ECO:0000313|EnsemblMetazoa:HelroP169856};
GN ORFNames=HELRODRAFT_169856 {ECO:0000313|EMBL:ESO08121.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP169856, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO08121.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP169856}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
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DR EMBL; AMQM01003405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096134; ESO08121.1; -; Genomic_DNA.
DR RefSeq; XP_009013910.1; XM_009015662.1.
DR AlphaFoldDB; T1F2D6; -.
DR STRING; 6412.T1F2D6; -.
DR EnsemblMetazoa; HelroT169856; HelroP169856; HelroG169856.
DR GeneID; 20202986; -.
DR KEGG; hro:HELRODRAFT_169856; -.
DR CTD; 20202986; -.
DR eggNOG; KOG1124; Eukaryota.
DR HOGENOM; CLU_023648_0_0_1; -.
DR InParanoid; T1F2D6; -.
DR OMA; CCKETIL; -.
DR OrthoDB; 5476391at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR040111; ODAD4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23040:SF1; OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR23040; UNCHARACTERIZED; 1.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 3.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 26..59
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 60..93
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 287..320
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 410 AA; 48213 MW; 3DD6B4F738A8A1AF CRC64;
MKSSNKYPNL HNEWQVQSLA LEKNNAMTLI HRSYCNLKLE NVNKAMKDVN EALKLQPKNI
AALLQKADTY YFMGKLEEAL VHYYRSQKLS PRLQRCHLWV YICETAILKI IGDSRMLLTK
NGDLSFLEKQ VEENSVSRNK TLEVKLKDKF KQKQKVSKNR RTLKLMGSLY EDRCYLESIF
LEAGDHTRVG SKLKHRAYTL IQYIDKQTMK MLHEKPPTKI IKRSKPLPSI TEARMCINQA
ITRELNLIDT EQQEHLYCES LQRCYNLLNA VLNYKEEVVK KLEEVIATIY GYMGTAYLQG
KDMDKAMMFF KKEKDLSIRH WSILLPTIEE AEERSWLLHE MGRCYYALCD FNRALELGEK
AYEEAKKTRD YFWMITCLVL MAQSRIRIPD LNAAFLDYEN ALYLALSMSK
//
