ID T1F948_HELRO Unreviewed; 287 AA.
AC T1F948;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=BRICHOS domain-containing protein {ECO:0000259|SMART:SM01039};
GN Name=20205347 {ECO:0000313|EnsemblMetazoa:HelroP175309};
GN ORFNames=HELRODRAFT_175309 {ECO:0000313|EMBL:ESO00821.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP175309, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO00821.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP175309}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the chondromodulin-1 family.
CC {ECO:0000256|ARBA:ARBA00009898}.
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DR EMBL; AMQM01005214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096864; ESO00821.1; -; Genomic_DNA.
DR RefSeq; XP_009020992.1; XM_009022744.1.
DR AlphaFoldDB; T1F948; -.
DR EnsemblMetazoa; HelroT175309; HelroP175309; HelroG175309.
DR GeneID; 20205347; -.
DR KEGG; hro:HELRODRAFT_175309; -.
DR CTD; 20205347; -.
DR HOGENOM; CLU_970696_0_0_1; -.
DR InParanoid; T1F948; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007084; BRICHOS_dom.
DR InterPro; IPR043405; Chondromodulin/Tenomodulin.
DR PANTHER; PTHR14064; CHONDROMODULIN-RELATED; 1.
DR PANTHER; PTHR14064:SF5; LEUKOCYTE CELL-DERIVED CHEMOTAXIN 1; 1.
DR Pfam; PF04089; BRICHOS; 1.
DR SMART; SM01039; BRICHOS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..186
FT /note="BRICHOS"
FT /evidence="ECO:0000259|SMART:SM01039"
SQ SEQUENCE 287 AA; 31962 MW; C9417958B5175F19 CRC64;
MKPELELGSK ETPAVVFVEP PRAPKLTERK YFKVGIIVSI VLLAVLIICA VAGILAYIGV
QNKLIEYKLT GPEGRTQEVS GDLTENVVKY HIQDSDQDAW VVNDFNTDIK VTKIVNKMGT
NCYVSPLNRS NAMEPAKITV PKSSVMQEPS DFVSIVFKIS GEPIGDISFM NKKAKEMCKG
LSTYWMYPTC AKDDTLTSVP KNPANSSSIQ KRAAPFYVYS TYYYRGLNYP CFNACCRTIC
APYVSVYSVL KSGVMQCYWV TSGTRVRDIC YPTPGLVCRR PAIFPIC
//
