ID T1FB20_HELRO Unreviewed; 1042 AA.
AC T1FB20;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Calcium-activated potassium channel BK alpha subunit domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20206019 {ECO:0000313|EnsemblMetazoa:HelroP176931};
GN ORFNames=HELRODRAFT_176931 {ECO:0000313|EMBL:ESN98456.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP176931, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98456.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP176931}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMQM01005882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097144; ESN98456.1; -; Genomic_DNA.
DR RefSeq; XP_009023412.1; XM_009025164.1.
DR AlphaFoldDB; T1FB20; -.
DR EnsemblMetazoa; HelroT176931; HelroP176931; HelroG176931.
DR GeneID; 20206019; -.
DR KEGG; hro:HELRODRAFT_176931; -.
DR CTD; 20206019; -.
DR eggNOG; KOG3193; Eukaryota.
DR HOGENOM; CLU_003370_0_0_1; -.
DR InParanoid; T1FB20; -.
DR OMA; GMANSHY; -.
DR OrthoDB; 2907493at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005228; F:intracellular sodium-activated potassium channel activity; IBA:GO_Central.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF10; SLOWPOKE 2, ISOFORM D; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1042
FT /note="Calcium-activated potassium channel BK alpha subunit
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010980455"
FT TRANSMEM 71..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 177..240
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 404..496
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 564..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 118910 MW; 7F2E2DD7A87A634A CRC64;
MFNVVMKLLS CVLYVARVVM EENLCGHPRN GFAFDPGSSA AAATVDNDTL SSATAASTTT
TISILWVCRH VWFWAIQVTV AIISLLETLL VTYLSYKGNL LQQIVTPEFI LELVTTVPFI
ITLFYPPIKD LFVPVFLNCW LAQMALSNML NDLNRVRQKS HSALAQQLFI LLATFLCLIF
TSVCGFQHLQ RGSSKTKVSL FNSLWFVIVT YSTVGYGDMY PDIWPSKLFI MLLICTSFIV
LPKQIDALAH TWMERQKMGG SYSSHRAYNE KHVVVVSTIL QSDVIMDFLN EFYAHPKVQD
YFVVLLSPSE MDDTLKLILQ VPIWAARVIY IRGSALKDSD LSRCRLQDAY ACFFIVSRNQ
DKMASDQHTI LRSWAVRDFA PQVTQYLQIF KPENKLHVYF AECLVCEDEF KYSLLANNCL
FPGISTFMTL LLHTSDGLEG QHCEQEWMRV YGKYSGNEMY HVLARTSIFF GEYVGKSFTF
ASFNAHRKYG VCLVGVVSEG KSEHMFLNPG SGYLLKESDV CLYLSLSKEE NAYITRSDKE
QRMIDSSKKS TSFQERDILD PEKGVESGPA LRQHQQTTSN ALDLSDYPDD YTLGIPPVSP
YIGVTPHICH LLRRKRALCC LVINETCEHI DKTQASDYDW KNKCTIVIAD VVSTALFNFV
MRMRGRNVNH RLLQPIIIVV EKDRPDASFL DSISYFPEVY WMIGSIDCLD DLLVAGITQS
HNIVVVNKEL SNAIEEDTLA DCNTLVAVQT IYRLFPTLNI VMELSQASNM RFMRFRPKDS
TQMKFSKIEK RERENGSHLY FMFRLPFAAG CVFSASMLDT ILYQAFAKEN VIQFVRMILG
IDEHPMSGHL SSIKITSEEI WVGTYGRLYQ KLCSTTREIP IGIYRTQENM TTLGILETIT
NYDVVDYKTC RETENMVRCR MESLGLACRR MAEQMRGDVP LNDLIQQHHH PEQQQPQEQP
QQQCDNHESA IVRDINQKPL ENVWGKKEAL SYVIINPSND LELQLDDIIA PLFKPGEHPQ
ERNLHKKGPS IRKGPFIKNG PP
//
