ID T1FMF7_HELRO Unreviewed; 818 AA.
AC T1FMF7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Peptidase M28 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20210006 {ECO:0000313|EnsemblMetazoa:HelroP185132};
GN ORFNames=HELRODRAFT_185132 {ECO:0000313|EMBL:ESN94716.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP185132, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN94716.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP185132}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; AMQM01001725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097571; ESN94716.1; -; Genomic_DNA.
DR RefSeq; XP_009027749.1; XM_009029501.1.
DR AlphaFoldDB; T1FMF7; -.
DR STRING; 6412.T1FMF7; -.
DR EnsemblMetazoa; HelroT185132; HelroP185132; HelroG185132.
DR GeneID; 20210006; -.
DR KEGG; hro:HELRODRAFT_185132; -.
DR CTD; 20210006; -.
DR eggNOG; KOG2195; Eukaryota.
DR HOGENOM; CLU_005688_3_2_1; -.
DR InParanoid; T1FMF7; -.
DR OMA; HMAGTPG; -.
DR OrthoDB; 2428249at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IBA:GO_Central.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 189..274
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 370..473
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 686..809
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 519..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 818 AA; 91773 MW; 40661CF7B1B32A17 CRC64;
MMNYYYNSLN SMDKSFRSKM KRKIDTVGVL KIVALILSAA ILLVLGFVIG YFTKTAVTHH
TSSESVGISE VDVADYLMKE ISSENIDKHL KKLTSRPHLS GTPGIHDTVE YIHNFWKQIH
LDKTKLISYE VLLSHPSPDN PNSVSVLGQD DSPLFQSQPA EPILRPEDNS SEIVPPFNAY
SAAGSVMGTP IYVNYGRVSD FEYVKNLNMT FKDQICVVRY GFNFRADKVA LGEKYGCVGM
IIYSDPADYA ITNTSKVYPD SWLIPGGGVQ RGTIKKSSTA SGDPLTPLYP ATEHAYRLNI
SEADLPKIPC QPIGYDDARK LLRYFDGEEV PDEWKGGLNI TYRFGSKLIS GAKAVKVVVN
NEFKLDTINN IVGFIEGSVE PDRYVIIGNH YDAWVYGGAD PNSGTAVMLE VSRAFMALTK
EKGWRPRRSL MFCAWGAEEQ GIIGSREFVE EYGLILGQRA VAYLNVDIAV QGRFVFRGKA
LPMLNTVLFE ATKLVPNPDE EEVEHGRKSV YDTWCFRKPE KSSSSSPTSL SSSPSSPNHA
VIIDRDDKSH SNYVTIYKDD DDIDDGVVKP IRPRMGLIGS GSDFAPFVIS VGTTCADVRF
IYDEKLNISS YPLYHTGYET YYLFSKHHDP GFIYSKALGR VWSQMALMLA DRVQIPLDPV
EYSDFVKSYF QKFKSSNERY LLGFNITLTA LSSAVKNFTR AVKDFKARLD KIDLNNVHLV
RQYNDQLMNL ERSFIDHAGL PDRPAVKHVI FAPSRYNSYA ASVFPGVTDA IFDLKQHLHD
GEAPKYVEQV KKQLSVLIFM FQRAGANLKE SDDFIGRD
//
