ID T1FNB7_HELRO Unreviewed; 545 AA.
AC T1FNB7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0000259|PROSITE:PS50188};
GN Name=20210314 {ECO:0000313|EnsemblMetazoa:HelroP185811};
GN ORFNames=HELRODRAFT_185811 {ECO:0000313|EMBL:ESN99523.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP185811, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN99523.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP185811}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AMQM01005804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097106; ESN99523.1; -; Genomic_DNA.
DR RefSeq; XP_009022297.1; XM_009024049.1.
DR AlphaFoldDB; T1FNB7; -.
DR STRING; 6412.T1FNB7; -.
DR EnsemblMetazoa; HelroT185811; HelroP185811; HelroG185811.
DR GeneID; 20210314; -.
DR KEGG; hro:HELRODRAFT_185811; -.
DR CTD; 20210314; -.
DR eggNOG; KOG2626; Eukaryota.
DR HOGENOM; CLU_032370_2_0_1; -.
DR InParanoid; T1FNB7; -.
DR OMA; CATCSRW; -.
DR OrthoDB; 5479497at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR CDD; cd15583; PHD_ash2p_like; 1.
DR CDD; cd12872; SPRY_Ash2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.90.980.20; -; 1.
DR InterPro; IPR037353; ASH2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR PANTHER; PTHR10598; SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2; 1.
DR PANTHER; PTHR10598:SF0; SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2; 1.
DR Pfam; PF21198; ASH2L-like_WH; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 279..505
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 545 AA; 61746 MW; 1751AE8DC976E71B CRC64;
MEPIEAKVCT ESAADDVPSA VGAGGSTLLP ANPEDKTCYC GRDRNLNICE FQCGMCLRYY
HETCVSCYNR DCVPFMTNYQ FFCKRCSMQE SLMKRQASFG QMCLTAIANL MQKNKGKTMF
SKDADIIPYI ETNWELLTSS PRRVKNTWHS SISKTMLKDP SIFTTKEGGA DTTFGLVNED
LSKIGPNCES LLRLLCNRPV ETKTQVQTEA TRGRLAKRKT PGEHHYVVGS KQKKSEMTST
MRLAPSCYPA EHPFNKDGYR YHLAEPDPHA PNWQIFDESP EWAGKPIPGY LYRMNLEANV
LLSLNDRAPQ LKVSDDRLTV TGEKGYSMIR ANHGVNEGSW FYEVKIDDMP ADSATRIGWS
QSLGNLQAPC GYDKFSYSWR SKKGTIFHQS RGKHYCDSGY REDDLLGFLI RLPRQADECH
LQLLPPQYKE KPLVKFKSHL YYEEKDLVAE TESKLKPAAG SQIIMFLNGK CQGIAYEDIN
KGIYFPAISS YKNATVSVNF GPKFKYPPKD YQYRPMCQAT EASAVQHALG DILYHVEHEG
QTLEI
//
