ID T1FQS7_HELRO Unreviewed; 665 AA.
AC T1FQS7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Coiled-coil domain-containing protein 22 homolog {ECO:0008006|Google:ProtNLM};
GN Name=20211174 {ECO:0000313|EnsemblMetazoa:HelroP189209};
GN ORFNames=HELRODRAFT_189209 {ECO:0000313|EMBL:ESN96352.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP189209, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN96352.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP189209}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CCDC22 family.
CC {ECO:0000256|ARBA:ARBA00006438}.
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DR EMBL; AMQM01001383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097495; ESN96352.1; -; Genomic_DNA.
DR RefSeq; XP_009025529.1; XM_009027281.1.
DR AlphaFoldDB; T1FQS7; -.
DR STRING; 6412.T1FQS7; -.
DR EnsemblMetazoa; HelroT189209; HelroP189209; HelroG189209.
DR GeneID; 20211174; -.
DR KEGG; hro:HELRODRAFT_189209; -.
DR CTD; 20211174; -.
DR eggNOG; KOG1937; Eukaryota.
DR HOGENOM; CLU_024231_1_0_1; -.
DR InParanoid; T1FQS7; -.
DR OMA; FHENCSQ; -.
DR OrthoDB; 9179at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR008530; CCDC22.
DR InterPro; IPR048348; CCDC22_CC.
DR InterPro; IPR048349; CCDC22_N.
DR PANTHER; PTHR15668:SF4; COILED-COIL DOMAIN-CONTAINING PROTEIN 22; 1.
DR PANTHER; PTHR15668; JM1 PROTEIN; 1.
DR Pfam; PF05667; CCDC22_CC; 1.
DR Pfam; PF21674; CCDC22_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 39..123
FT /note="CCDC22 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21674"
FT DOMAIN 142..630
FT /note="CCDC22 coiled-coil"
FT /evidence="ECO:0000259|Pfam:PF05667"
FT REGION 316..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 368..479
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 665 AA; 75678 MW; CE00BB71DC0C688F CRC64;
MKWECQEKKG SEQWTGRTII IQGSQMDRAI LRPPDLDGIS GVGQLSAENV VDAVGRCIRL
IDPSVDVKCK LPSNMAAKYR VGTQLADAVK GLNYQGEVGY HTFLYVNEVE MRKIFSFLIS
RLPKDRSIIE QECLTPQVLL RRSINQTINH LLKQAWLPPY CCIKEEKVKR PFNAHVMLVP
NQFDRQNNIP QELQKYYSHH LPLSTQQFAN KSTTSTNNSN NKTSILFCSI LQYNSLKVAQ
ERRERYNNNI ISSSSGSDNL KDSILSKKSK ENILSKISSQ IKESLKHTNI ASSSAQLTSS
SLLSSSSSSS SSKFRAKQKM LATSPSSSSS SSSQSHVLSN VEADKQLTDT KPILEVAVPV
GKDEDEELRD LEDKLKKFVG ELNEKGEMME SLKEHLHQMK GQISDLTNEN KRRKAEAKMK
KKMIGLLPEA QESIVQLENV VSEAEQRLAA MMNQWEDRKK QLEEELIGLQ IRSDNNETRR
DHLLDELNEV RCNLKLASGQ AQEKNLLHKQ LLIELEKMTT HGPSRSTYTT RILEIVANIM
KQNQEIEKIL VDTRSVQKEI NQVSGVLERT FIVTDELLFK NAKSDETSRR AYKLLASLHE
NCSSLVKSVE EIGEITKETR DIEEQLEIER DNQTEESLER ISNDFKLIKL ENQQLIQQLK
SKMTT
//
