ID T1FQV8_HELRO Unreviewed; 893 AA.
AC T1FQV8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Glutamate receptor {ECO:0008006|Google:ProtNLM};
GN Name=20211205 {ECO:0000313|EnsemblMetazoa:HelroP189260};
GN ORFNames=HELRODRAFT_189260 {ECO:0000313|EMBL:ESN96469.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP189260, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN96469.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP189260}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMQM01001393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097495; ESN96469.1; -; Genomic_DNA.
DR RefSeq; XP_009025625.1; XM_009027377.1.
DR AlphaFoldDB; T1FQV8; -.
DR STRING; 6412.T1FQV8; -.
DR EnsemblMetazoa; HelroT189260; HelroP189260; HelroG189260.
DR GeneID; 20211205; -.
DR KEGG; hro:HELRODRAFT_189260; -.
DR CTD; 20211205; -.
DR eggNOG; KOG1054; Eukaryota.
DR HOGENOM; CLU_007257_1_2_1; -.
DR InParanoid; T1FQV8; -.
DR OMA; HANPDIG; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0008066; F:glutamate receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0035249; P:synaptic transmission, glutamatergic; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF600; GLUTAMATE RECEPTOR 1-RELATED; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 401..766
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 411..473
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 823..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 100634 MW; 616D2DFF06243646 CRC64;
MLDSEKSKQY DIMKMIRYGV GKYYKSKSSE DRMRNHFEEE INEVNMDNSF RVGTSICNLV
TKRIVALLGI HTSNTLNTVK SYSNTFNIPY ITTAMAVNSS KQEHGFQLFL RPMYIRAVFD
LIKYYQWKEA FYLYSTNEGL ERLQQLFDII TEEGYPLKIK VYRVENASEV LEALSKITNL
DYKRLLLDLP AHETESVINK TFELNTSKNV KHVIILMGLN LNEMISQAFK LGGLNVTGLC
LVDHAKKRSL IRDWHSVYKG VDITSDLPMP GEAALLADAA FLMAHALAKV FKHKTPLNDH
SPYSNGFFGE ALSCETEPTV PWKFGSEVIK ALKETNLTGL FTGPLVFDEF GLRKHYTMDV
LESRLNGPLM KFGTWDTTHG LTVIQNAHVR TKGNNTIANK TRIVTSVFSA PFLMLRTEPD
LVGNDRFEGY CANLTKKIAD LIKFDYQLQP VKDNKYGSND TGTWDGMVGE LLRGEADMAI
APLTITADRE SVIDFSKPFM SLGISIMIKK MSKKPPNVFS FMDPLSYEVW MCIIFAYIGV
SVVLFLVSRF SPFEWHVDDK QDSVANNFTI FNSLWFSLGA FMQQGVDIEP RSMSGRIVGS
VWWFFTLILI SSYTANLAAF LTSERMQSPI ESAEDLAKQT EIKYGTIKGG STQGFFKKST
IPTYERMWAF MSSSEPWVFV DTTDAGVNLV REKKGKYAFL TESTQNEYTN QRKPCDTMKV
GSNLDAKGYG IGTPMGSDLR DRITLSVLEL HETGELATLF TEWWFNKGQC GKEGPPKKQE
ATSSLKLPNV TGIFYILMGG LILSLFIAAI EFFHKTRHEA KKRKTSFARA ARSGARLSLT
GQPHEPFSAD ETPDSQPGDI PPNMNMSTYS YGPPPGQLLN IDGYGDSNMQ TQV
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