ID T1FRS7_HELRO Unreviewed; 744 AA.
AC T1FRS7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN Name=20211524 {ECO:0000313|EnsemblMetazoa:HelroP190227};
GN ORFNames=HELRODRAFT_190227 {ECO:0000313|EMBL:ESO10895.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP190227, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO10895.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP190227}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01002774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095858; ESO10895.1; -; Genomic_DNA.
DR RefSeq; XP_009011164.1; XM_009012916.1.
DR AlphaFoldDB; T1FRS7; -.
DR STRING; 6412.T1FRS7; -.
DR EnsemblMetazoa; HelroT190227; HelroP190227; HelroG190227.
DR GeneID; 20211524; -.
DR KEGG; hro:HELRODRAFT_190227; -.
DR CTD; 20211524; -.
DR eggNOG; KOG4270; Eukaryota.
DR HOGENOM; CLU_373513_0_0_1; -.
DR InParanoid; T1FRS7; -.
DR OMA; QLATEMY; -.
DR OrthoDB; 7959at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0035020; P:regulation of Rac protein signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF14; RHO GTPASE-ACTIVATING PROTEIN 92B; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 196..371
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 416..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..457
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..549
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 82861 MW; EB81E86DF3731840 CRC64;
MAASSFRKQI QRVRQNIDQN LGRAEKTEVL NEEELNLERR VELLKMVCQN IQKKLVLCVK
SPSQITETDK RLRKIPEHGL WQTLKESSVQ LTENTPSSQI FDLASGLQHN LATEIIMLDI
LIENNSLKFL QNILEDQLAT EMYSFSSKEV EINQSLLELV EAQAEFLRKS LAYFDKAIPR
IKECFDFSVH KPVFGQSLSE HVEKRGNRDI ALVLEECVQF LYEHALEEES AFNSNISSGS
VIAGVDEVDV NVIASVLKQY LRELPDPLMT CDLYNEWMKA NELPADQVAN YLKDVAAKLP
RINYVNLRYL IKFLKKLSEC SDVNKMSPAN IGLVMGPNLI WAPGDVGPNM LTTGMQSSLV
EMLVVHSNAI FPGEINFTTT SNESPETNFE YKKFAAISLN DPSIHVKQQQ YNILPSYSTQ
PDNKKCDDDD LCNNVDGDGD DDNDDDVVDD DENDKESEAD VSSSTTPQQQ KQQQVQPPQQ
QQIISQTPAS TTMKRIKKQQ APQPPPDGLV TSFSHLMTTS EYTPVTRLEK PRVPPPERPT
MPPPDKPVRS NVEPQAAAPS PGFILPATMK QQPQQVAPQV QTMPQPQLPD VAMLPSHAAT
PTNQFNNDPH QQQQQQQQQQ QQQQQVINSN ISSSDSNISS PHASSAPLNQ QQQPQQRISL
TSPSVLSSSF NQSSTSATPS SNIPPKPNYP YLGPSESPGA QATPGSPKPA PKTHSRNSSL
GSKPPPPRPH PPLPPKRFEQ KPGE
//
