ID T1FVP8_HELRO Unreviewed; 428 AA.
AC T1FVP8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN Name=20212894 {ECO:0000313|EnsemblMetazoa:HelroP194116};
GN ORFNames=HELRODRAFT_194116 {ECO:0000313|EMBL:ESN93290.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP194116, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN93290.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP194116}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01007445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097620; ESN93290.1; -; Genomic_DNA.
DR RefSeq; XP_009028571.1; XM_009030323.1.
DR AlphaFoldDB; T1FVP8; -.
DR STRING; 6412.T1FVP8; -.
DR EnsemblMetazoa; HelroT194116; HelroP194116; HelroG194116.
DR GeneID; 20212894; -.
DR KEGG; hro:HELRODRAFT_194116; -.
DR CTD; 20212894; -.
DR HOGENOM; CLU_058449_1_1_1; -.
DR InParanoid; T1FVP8; -.
DR OrthoDB; 3027035at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098632; F:cell-cell adhesion mediator activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0070593; P:dendrite self-avoidance; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF100; CONTACTIN RIG-6; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 382..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..96
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 115..204
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 221..372
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 281..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..313
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 49387 MW; 3BF26DC624BA1A7A CRC64;
MEPVYLKVGD QLKLTCEQNG NFRTAWLRHT SKRKLDEENE IYTDDNKYEK VHEGFILKSY
SKDGRFINTL IKENVTEDDA GSYKCEVLNN LQRSYAVDVN IFRSNLTFFD TFYHPFEISL
IVTALNGISQ GTGNQTVLGC VLHSDTRSYP EVEWRRNEKI INIDDSHNKY IINTSLRIDS
SDFYTTLTIK RTNDQDSGLY TCSMRFGPIW FNQTVQLFAP PNVRILDRSI SSSEGSQVEV
VCVVFGWPTP VISWLRSDNS SISKNRHQRI YYSTPYEILD NDYDNDADGE EDDDDADRDM
SSDYDEDKDN DDRDDDPQMT SNKKSKFSSG KFQMINSTLI ITDVQMSDRD IYICEAIAYV
NDSVALKSRS MVLLRVKGKY AFIYPLIGII IEFVVLLTII VFYERKRKKE AATEEVVAPV
AQDDIFNH
//
