ID T1FYH7_HELRO Unreviewed; 247 AA.
AC T1FYH7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
GN Name=20213875 {ECO:0000313|EnsemblMetazoa:HelroP66160};
GN ORFNames=HELRODRAFT_66160 {ECO:0000313|EMBL:ESO02218.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP66160, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO02218.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP66160}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01000823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO02218.1; -; Genomic_DNA.
DR RefSeq; XP_009019626.1; XM_009021378.1.
DR AlphaFoldDB; T1FYH7; -.
DR STRING; 6412.T1FYH7; -.
DR EnsemblMetazoa; HelroT66160; HelroP66160; HelroG66160.
DR GeneID; 20213875; -.
DR KEGG; hro:HELRODRAFT_66160; -.
DR CTD; 20213875; -.
DR eggNOG; KOG4177; Eukaryota.
DR HOGENOM; CLU_093013_0_0_1; -.
DR InParanoid; T1FYH7; -.
DR OMA; GANIHCE; -.
DR OrthoDB; 5479875at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01670; Death; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR PANTHER; PTHR24125; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24125:SF5; REPEAT PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00531; Death; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 8..40
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 40..72
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 73..105
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 180..247
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 247 AA; 27704 MW; 95C67E712123E092 CRC64;
MEQYTPQMDR SGLHYASANG HDQIVNQLLD SGADYDANDK GNTPLYSAAE NDHPKIVQFL
LNNGADVNAE NIRLQTPLHI GVEKASVEVV DVLLHAGADL HIQEKSGKTA LGIASRGSLI
GIVDMIIKAE HDQCCDKENL SNVTHSKTRM SHSATAHNEV SDYLKSVFWK LATKQLKPND
WKMLAKHWQF TDNHIKAIEH QYTGNESYKE HGYRLLLIWY HSLEKNENPI KKLFEGLVAI
GQRELAG
//
