ID T1FZ52_HELRO Unreviewed; 484 AA.
AC T1FZ52;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=PHD finger protein 10 {ECO:0000256|ARBA:ARBA00016995};
GN Name=20214100 {ECO:0000313|EnsemblMetazoa:HelroP67786};
GN ORFNames=HELRODRAFT_67786 {ECO:0000313|EMBL:ESN96294.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP67786, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN96294.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP67786}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SAYP family.
CC {ECO:0000256|ARBA:ARBA00006097}.
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DR EMBL; AMQM01001376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097495; ESN96294.1; -; Genomic_DNA.
DR RefSeq; XP_009025135.1; XM_009026887.1.
DR AlphaFoldDB; T1FZ52; -.
DR STRING; 6412.T1FZ52; -.
DR EnsemblMetazoa; HelroT67786; HelroP67786; HelroG67786.
DR GeneID; 20214100; -.
DR KEGG; hro:HELRODRAFT_67786; -.
DR CTD; 20214100; -.
DR eggNOG; KOG1512; Eukaryota.
DR HOGENOM; CLU_028634_2_0_1; -.
DR InParanoid; T1FZ52; -.
DR OMA; ECKRCTI; -.
DR OrthoDB; 5490909at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0071564; C:npBAF complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd15528; PHD1_PHF10; 1.
DR CDD; cd15529; PHD2_PHF10; 1.
DR CDD; cd21085; WH_NTD_PHF10; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR038045; PHF10_PHD_finger_1.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF8; PHD FINGER PROTEIN 10; 1.
DR Pfam; PF00628; PHD; 2.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 354..405
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 226..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 55320 MW; 1373B2D4F82EDF36 CRC64;
NIVEYQWPQA RNAPWYILQE HISEYLGVLS FKRKYPNISR RPVEYQERQY LIDQGCVTEV
QCDLGLTVLN AEEVLKLMSK DYPEKYQAAI FVSKLINKMI TIWKQHYAGI YKIQQEKIEV
TKLENLMKKA IKSAAEFNAS LCKDRRQARS MYIDLQTMEL HKPQSRKAVV NYSSVNLCDS
YPVALVPGQY QHYYKRYTPT ELNYFPLNTA LYAPPKMMQS IYVDPNQPEK EASDEDVEQE
EAVDDLTSSN NRPTRTRTTL SNNKKFQPFS TSSITNEDSN TSFGSEKKIR KGGPGRGKKV
NSVRCGMCSQ TTKNKYNEPD DLIKCNTCNV SNHPGCLGLS AEMVPMIKTY DWQCMECKVC
YQCTQPHDED KMMFCDNCDR GYHTYCVGLI SIPEGRWDCV MCTTNNNINE SIINNNTNDS
SSNINFTENS NSVASNDNSN IGFSFFQNNS FKFPSSFSPT AQTGVGALSN ISRPSSLKSR
FQFL
//
