ID T1G105_HELRO Unreviewed; 716 AA.
AC T1G105;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=IF rod domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20214753 {ECO:0000313|EnsemblMetazoa:HelroP72466};
GN ORFNames=HELRODRAFT_72466 {ECO:0000313|EMBL:ESO10968.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP72466, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO10968.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP72466}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|PIRNR:PIRNR005546, ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01002787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095858; ESO10968.1; -; Genomic_DNA.
DR RefSeq; XP_009011237.1; XM_009012989.1.
DR AlphaFoldDB; T1G105; -.
DR STRING; 6412.T1G105; -.
DR EnsemblMetazoa; HelroT72466; HelroP72466; HelroG72466.
DR GeneID; 20214753; -.
DR KEGG; hro:HELRODRAFT_72466; -.
DR CTD; 20214753; -.
DR eggNOG; KOG0977; Eukaryota.
DR HOGENOM; CLU_012560_7_0_1; -.
DR InParanoid; T1G105; -.
DR OMA; VMFESEL; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0005652; C:nuclear lamina; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0031507; P:heterochromatin formation; IBA:GO_Central.
DR GO; GO:0006998; P:nuclear envelope organization; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR GO; GO:0051664; P:nuclear pore localization; IBA:GO_Central.
DR GO; GO:0090435; P:protein localization to nuclear envelope; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR016451; Intermed_filament_ifa/ifb.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721:SF12; INTERMEDIATE FILAMENT PROTEIN IFA-1; 1.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR PIRSF; PIRSF005546; Intermed_filamnt_Ifb-2; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PIRNR:PIRNR005546};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|PIRNR:PIRNR005546};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 169..527
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 598..714
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 439..526
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 80012 MW; 626A5867931C2358 CRC64;
MERERERERD RDRAESYKRK EVIKETYIDE SKGRGGGTTT TRHEERETSG YGGGSSRGGA
SSYGGGTSGY TSGGAGGGTS STYRERVVTS SSSSERPIYR PIVTPRSLVI QRSAVAPYTF
RTGGVGGRSF SVERSFQYGA GSRGGFTPEA YGAMTHSNVS SMMESREKEK RDMQDLNERF
ASYIEKVRFL EAQNRKLADE LEKLRASWGK ETSAVKAMYQ TELEESKKLL DDSERDKAKL
EIRVASLEEQ LDETRQREMD ARRDADDWRE RAEKQNQQLS DQEAEISMLR RRVNAFETDK
DKEKKQIAYL TDALNRARFD LDNETLQHVD AENRRQTLEE ELEFLKAIHE QASIHKLAAL
AYRDTTPENR EFWKNEMGQA LREIQQVYDD KLDNIRSEME FFYNTKIQEY TTNIQRQGGP
GADLTSRNKE ESRKMRTYIS ELNEKMSSLD SKNAQLIREL EIMRRDRDER EREWERENGD
LKVEVAKLRA ELEAILKELQ NIMNAKMGLE LEIEAYRKLL ETEETRLVLM RRGDVYPGYG
GGGSSISGGG GGGGKGGGGS YGGGGSYGGG GSYGGGGSYG GGGSSSGAQH PPTDRTPSRT
SFQRSSKGPV SVAECSPDGK FITLENTGQK DEFIGGWMLS RVVDDREKVG TVLPSDIVLR
SGEKMRVWVR GTKPLNASAL DIECSIPNWG VGANAATKLT NVAGEERATH VQKTTY
//