ID T1G1J6_HELRO Unreviewed; 583 AA.
AC T1G1J6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN Name=20214944 {ECO:0000313|EnsemblMetazoa:HelroP73864};
GN ORFNames=HELRODRAFT_73864 {ECO:0000313|EMBL:ESO09432.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP73864, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO09432.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP73864}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; AMQM01002959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095959; ESO09432.1; -; Genomic_DNA.
DR RefSeq; XP_009012525.1; XM_009014277.1.
DR AlphaFoldDB; T1G1J6; -.
DR STRING; 6412.T1G1J6; -.
DR EnsemblMetazoa; HelroT73864; HelroP73864; HelroG73864.
DR GeneID; 20214944; -.
DR KEGG; hro:HELRODRAFT_73864; -.
DR CTD; 20214944; -.
DR eggNOG; KOG2165; Eukaryota.
DR HOGENOM; CLU_007149_4_2_1; -.
DR InParanoid; T1G1J6; -.
DR OMA; FMYETFA; -.
DR OrthoDB; 2786196at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044554; APC2-like.
DR InterPro; IPR014786; APC2_C.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR Pfam; PF08672; ANAPC2; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01013; APC2; 1.
DR SMART; SM00182; CULLIN; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 233..466
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 583 AA; 67289 MW; A9522C2055C4DB4E CRC64;
CQCNSTLKKF NDFFKLLHNL KIIELVITEP MIELIFEKID NHLELQCKSS YDKSYIKDIY
KWIEKLIISW PDEILFKSLE KNESSIRFLS NYAKKFKYYA ANIYGKMRID QLFDIIIEYP
DSLPVLMDLI ECLKLVPELK MILVYSLKQA LKLRLLHPGV NTGDILTAYI STMRALRILD
QSGVLLEMVG EPVKQYLKGR DDTVRCIVTS LTEDSNNDLS EELNKGYLLA DSDSEDELSC
LFNWETWNPD PVEAEPLRPS QASRSFDIIS MLVNIYGSKE LFIEEYRSLL ADRILTQLSY
DTVKEIKHLE LLKLRFGESQ LHQCEIMLKD VSDSRRISNI IQSRKQSVDA SDVIPINGMI
LSAQFWPPRL KDEKVKLPDC LINSMQHYKK SFELLKGNRT LIWKPHLGLV NMEIELKGKI
LTFNVSPIHA AIIWHFQSKP VYTVDELSSI MQMPTQALQR KIAFWQSQGL LKEDGVDTFR
VVDELKSTSQ DTMIVDEDTV ESVLVSSKDQ KEEELQIIWS YIVGMLTNLE SLSLERIHAM
LKMFAMQGPG SQCSLSDLKA ILELKLKELK LVYSNGVYRL PPS
//
