ID T1G430_HELRO Unreviewed; 64 AA.
AC T1G430;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Copper transport protein ATOX1 {ECO:0000256|ARBA:ARBA00040962};
DE AltName: Full=Metal transport protein ATX1 {ECO:0000256|ARBA:ARBA00043201};
GN Name=20215828 {ECO:0000313|EnsemblMetazoa:HelroP80629};
GN ORFNames=HELRODRAFT_80629 {ECO:0000313|EMBL:ESO03431.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP80629, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO03431.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP80629}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Binds and deliver cytosolic copper to the copper ATPase
CC proteins. May be important in cellular antioxidant defense.
CC {ECO:0000256|ARBA:ARBA00037651}.
CC -!- SIMILARITY: Belongs to the ATX1 family.
CC {ECO:0000256|ARBA:ARBA00038171}.
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DR EMBL; AMQM01004687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096633; ESO03431.1; -; Genomic_DNA.
DR RefSeq; XP_009018579.1; XM_009020331.1.
DR AlphaFoldDB; T1G430; -.
DR STRING; 6412.T1G430; -.
DR EnsemblMetazoa; HelroT80629; HelroP80629; HelroG80629.
DR GeneID; 20215828; -.
DR KEGG; hro:HELRODRAFT_80629; -.
DR CTD; 20215828; -.
DR eggNOG; KOG1603; Eukaryota.
DR HOGENOM; CLU_134973_3_1_1; -.
DR InParanoid; T1G430; -.
DR OMA; SCEGCAK; -.
DR OrthoDB; 1107952at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016531; F:copper chaperone activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006825; P:copper ion transport; IBA:GO_Central.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR46365; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR PANTHER; PTHR46365:SF1; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..61
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 64 AA; 7200 MW; 6E157A37710BEC41 CRC64;
KYVFKMEMTC EGCSNAAKRV LGRIGVDDVV ADLKEQKLFV TTDKSSKEVL ETLQKTGKKV
EMMN
//
