ID T1G9L2_HELRO Unreviewed; 586 AA.
AC T1G9L2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=WH1 domain-containing protein {ECO:0000259|PROSITE:PS50229};
GN Name=20217758 {ECO:0000313|EnsemblMetazoa:HelroP98248};
GN ORFNames=HELRODRAFT_98248 {ECO:0000313|EMBL:ESO08117.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP98248, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO08117.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP98248}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the Ena/VASP family.
CC {ECO:0000256|ARBA:ARBA00009785}.
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DR EMBL; AMQM01003405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096134; ESO08117.1; -; Genomic_DNA.
DR RefSeq; XP_009013906.1; XM_009015658.1.
DR AlphaFoldDB; T1G9L2; -.
DR STRING; 6412.T1G9L2; -.
DR EnsemblMetazoa; HelroT98248; HelroP98248; HelroG98248.
DR GeneID; 20217758; -.
DR KEGG; hro:HELRODRAFT_98248; -.
DR CTD; 20217758; -.
DR eggNOG; KOG4590; Eukaryota.
DR HOGENOM; CLU_466414_0_0_1; -.
DR InParanoid; T1G9L2; -.
DR OMA; QGPRVKH; -.
DR OrthoDB; 2884005at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0017124; F:SH3 domain binding; IBA:GO_Central.
DR CDD; cd01207; EVH1_Ena_VASP-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR038023; VASP_sf.
DR InterPro; IPR014885; VASP_tetra.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF22; PROTEIN ENABLED; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF08776; VASP_tetra; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF118370; Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 1..111
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 206..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 115..188
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 206..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..344
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 63874 MW; 81F0114069A7DFCC CRC64;
MGEHSIVAAK ASVMVYDEGN RRWVPSGTSQ GLSKIHIYQH PVNNTFRVVG RKLQDHELVI
NCAIMKGLKY NQATPTFHQW RDNRQVYGLN FSSKEEADDF AMAMFSALEM LTGSLNGTSQ
QQQLQQQQLQ QMQQQQKLQQ QLQQQQQQQH LTQGASYPQM QLHQQQILQQ QQQQYQQQQQ
MQQAQQMQKH YHQSLSNQQS MNFSTNQQQH QMNGYNMGDS KTLQMSSPSH AKSDLRSSTD
ALYSHPYEAA SLPRPNNAIN CSTNNSSNSF PSSQQQQMPP QTLPKNYATL PATGLSTAAI
LSQSPPVAPP IASSAVVPPA PPPPPPPPAA PCAPPPPPLP SEGVQRTPKP ASSPVAVNSL
ASALKSAQLR SVSKNNQNTP QSTDDSSSLE QAGMNYAAAT GTVGRSSITV AMIKGSENVM
SEMARKLKER RAKAEGTNDT TDLTINTTIA NNNHNTSTTS STSIDSATSN KHLNTSGNNV
DNNTSLSASS TGPLNGVLKS AGKSNGYESP RICRNSKRYQ SLTGQETFSL GGVTNSHQSS
SAATDSSCGV GDMEVLRQEI LSEVRKEINK AKMEILDAFQ AYFSKK
//
