ID   T1GDU9_MEGSC            Unreviewed;       751 AA.
AC   T1GDU9;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=HP domain-containing protein {ECO:0000259|PROSITE:PS51089};
OS   Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC   Phoridae; Megaseliini; Megaselia.
OX   NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA001500-PA, ECO:0000313|Proteomes:UP000015102};
RN   [1] {ECO:0000313|Proteomes:UP000015102}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Durham, NC isolate 2 -- Noor lab
RC   {ECO:0000313|Proteomes:UP000015102};
RA   Hughes D.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:MESCA001500-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC       {ECO:0000256|ARBA:ARBA00008418}.
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DR   EMBL; CAQQ02036262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1GDU9; -.
DR   STRING; 36166.T1GDU9; -.
DR   EnsemblMetazoa; MESCA001500-RA; MESCA001500-PA; MESCA001500.
DR   HOGENOM; CLU_002568_3_1_1; -.
DR   OMA; CWEGVHS; -.
DR   Proteomes; UP000015102; Unassembled WGS sequence.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 3.40.20.10; Severin; 6.
DR   Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR007122; Villin/Gelsolin.
DR   InterPro; IPR003128; Villin_headpiece.
DR   InterPro; IPR036886; Villin_headpiece_dom_sf.
DR   PANTHER; PTHR11977; VILLIN; 1.
DR   PANTHER; PTHR11977:SF57; VILLIN-LIKE PROTEIN QUAIL; 1.
DR   Pfam; PF00626; Gelsolin; 1.
DR   Pfam; PF02209; VHP; 1.
DR   PRINTS; PR00597; GELSOLIN.
DR   SMART; SM00262; GEL; 4.
DR   SMART; SM00153; VHP; 1.
DR   SUPFAM; SSF55753; Actin depolymerizing proteins; 6.
DR   SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR   PROSITE; PS51089; HP; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000015102}.
FT   DOMAIN          685..751
FT                   /note="HP"
FT                   /evidence="ECO:0000259|PROSITE:PS51089"
SQ   SEQUENCE   751 AA;  86282 MW;  0FC404069C6D9CE3 CRC64;
     QEDAKNCISE VKVDCTFRKV PKNAICFHIW RVEDDRIEAV CKASYGTFYD DSAYIIYASS
     PSGFSVNSET ITREVKTAAN FERYIHFWIG ERASSKKSGN VAFKVMELDS FLGNMTTNSE
     NRKTTKVLDL CLILRTVLLL SGLHRESHIP CRLFNLKGRN TLRVTEMPSI NWEHFCSDFI
     MVLKTEQNLF FWIGRSSHMS ERRLGLEMMP VFQETYKIND VVVVDDGYEQ AMTEIQKSDW
     NKYLNLRDRV VSQLAVPEKP PSNGFKLYKC GYKSGKYRIE EIKSSQPLQE DLIDSEAAYI
     IDGFAMGVWI WVGRLVNSTE KSESMRNARG FVKKKKYPSS TALVRVMDGI EPPEFIRLFP
     SWRRPTDPPQ SKSLGKIEAV VLAQRPKMAA ETQLIDDGTG ERKIYKFTEA IQGSEIPVTG
     SVKFASEYLV GSRFIVYIWN GKKVLNHIRS KADSFGIDLA KKLGNRTVLV KLEEGYESPH
     FLQIFKGKFI VFEKESLTLK AKPSEFVLRV TGDSSYNAKA MQINPLTELR SGNCYVLNST
     KNWVWCGQGS TGDTREIAKN IANLFGEYNL ALESKEPPQF WESIMKVFNP ENNNYTSVNG
     NGYLIENGDK LDVDKNKMRM FLVHNQKDTI FFHEFLVIEQ SDLHPENLYI IEVGDMIYVW
     IGKLASVSEE SCWKIAKRYM KESIIPIIEN KPISLRSTAE ADMLPEEVDP IRKEVHLTND
     DFISIFNMTY KDFEALPPWK QQELKKKNKL F
//